2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. eIF4A3-IN-9

eIF4A3-IN-9 (compound 57) is a silvestrol (HY-13251) analogue. eIF4A3-IN-9 interferes the assembling of eIF4F translation complex with EC50s of 29, 450 and 80 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-9 can be used for the research of human cancer pathogenesis.

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eIF4A3-IN-9 Chemical Structure

eIF4A3-IN-9 Chemical Structure

CAS No. : 1402931-71-8

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eIF4A3-IN-9 Related Antibodies

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Description

eIF4A3-IN-9 (compound 57) is a silvestrol (HY-13251) analogue. eIF4A3-IN-9 interferes the assembling of eIF4F translation complex with EC50s of 29, 450 and 80 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-9 can be used for the research of human cancer pathogenesis[1].

Cellular Effect
Cell Line Type Value Description References
MDA-MB-231 EC50
29 nM
Compound: 57
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
[PMID: 23025805]
MDA-MB-231 EC50
450 nM
Compound: 57
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
[PMID: 23025805]
MDA-MB-231 EC50
80 nM
Compound: 57
Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay
Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay
[PMID: 23025805]
Molecular Weight

505.52

Formula

C28H27NO8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@]12[C@](OC3=CC(C(N)=O)=CC(OC)=C32)(C4=CC=C(C=C4)OC)[C@H](C5=CC=CC=C5)[C@H]([C@H]1O)C(OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 99.71%

SDS (251 KB)

COA (262 KB) HNMR (228 KB) RP-HPLC (262 KB) MS (198 KB)

Handling Instructions (2659 KB)
References
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eIF4A3-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

eIF4A3-IN-91402931-71-8Eukaryotic Initiation Factor (eIF)myc-LUCtub-LUCMBA-MB-231natural producttranslationInhibitorinhibitorinhibit

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