2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. endo CNTinh-03

Endo CNTinh-03 is inhibitor for the elevation of cAMP and cGMP induced by agonist, such as G protein-coupled receptors, adenylate cyclase, and guanylate cyclase (IC50 is 4 μM). Endo CNTinh-03 inhibits cholera toxin- and Escherichia coli (STa) toxin- induced CFTR chloride current, ameliorates secretory diarrhea in mouse models, and prevents cyst growth in polycystic kidney disease model.

For research use only. We do not sell to patients.

endo CNTinh-03 Chemical Structure

endo CNTinh-03 Chemical Structure

CAS No. : 345288-49-5

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5 mg USD 145 In-stock
10 mg USD 230 In-stock
25 mg USD 465 In-stock
50 mg USD 740 In-stock
100 mg USD 1180 In-stock
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Based on 1 publication(s) in Google Scholar

endo CNTinh-03 Related Antibodies

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Description

Endo CNTinh-03 is inhibitor for the elevation of cAMP and cGMP induced by agonist, such as G protein-coupled receptors, adenylate cyclase, and guanylate cyclase (IC50 is 4 μM). Endo CNTinh-03 inhibits cholera toxin- and Escherichia coli (STa) toxin- induced CFTR chloride current, ameliorates secretory diarrhea in mouse models, and prevents cyst growth in polycystic kidney disease model[1].

Molecular Weight

427.51

Formula

C23H25NO5S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=C(NC(C2C(C3CCC2C3)C(O)=O)=O)SC(C)=C1C4=CC=C(C)C=C4)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (155.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3391 mL 11.6956 mL 23.3913 mL
5 mM 0.4678 mL 2.3391 mL 4.6783 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3391 mL 11.6956 mL 23.3913 mL 58.4782 mL
5 mM 0.4678 mL 2.3391 mL 4.6783 mL 11.6956 mL
10 mM 0.2339 mL 1.1696 mL 2.3391 mL 5.8478 mL
15 mM 0.1559 mL 0.7797 mL 1.5594 mL 3.8985 mL
20 mM 0.1170 mL 0.5848 mL 1.1696 mL 2.9239 mL
25 mM 0.0936 mL 0.4678 mL 0.9357 mL 2.3391 mL
30 mM 0.0780 mL 0.3899 mL 0.7797 mL 1.9493 mL
40 mM 0.0585 mL 0.2924 mL 0.5848 mL 1.4620 mL
50 mM 0.0468 mL 0.2339 mL 0.4678 mL 1.1696 mL
60 mM 0.0390 mL 0.1949 mL 0.3899 mL 0.9746 mL
80 mM 0.0292 mL 0.1462 mL 0.2924 mL 0.7310 mL
100 mM 0.0234 mL 0.1170 mL 0.2339 mL 0.5848 mL
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endo CNTinh-03 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

endo CNTinh-03345288-49-5endo CNTinh03endo CNTinh 03Phosphodiesterase (PDE)secretory diarrheapolycystic kidney diseaseT84CD-1 mousecholeraEscherichia coliInhibitorinhibitorinhibit

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