2. Apoptosis
  3. Apoptosis
  4. ent-Kaurane-3α,16β,17-triol

ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells.

For research use only. We do not sell to patients.

ent-Kaurane-3α,16β,17-triol Chemical Structure

ent-Kaurane-3α,16β,17-triol Chemical Structure

CAS No. : 130855-22-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

ent-Kaurane-3α,16β,17-triol Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells[1].

In Vitro

ent-Kaurane-3α,16β,17-triol (Compound 3; 0-100 μM; 24 h) shows IC50 values of 45.5 and 29.84 µM on HepG2 and HCT116 cells, respectively[1].
ent-Kaurane-3α,16β,17-triol (20 and 30 μM; 24 h) inhibits HCT116 cell colony formation[1].
ent-Kaurane-3α,16β,17-triol (30 and 40 µM; 48 h) induces cell cycle arrest in human colon cancer cells[1].
ent-Kaurane-3α,16β,17-triol (30 and 40 µM; 72 h) induces cellular apoptosis in human colon cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ent-Kaurane-3α,16β,17-triol Related Antibodies

Cell Viability Assay[1]

Cell Line: HepG2, MDA-MB-231, SCG-7901, OVCAR3 and HCT116 cells
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Showed inhibitory effects with IC50s of 29.84, 45.5, >100, >100 and >100 μM against HCT116, HepG2, MDA-MB-231, SCG-7901 and OVCAR3 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: HCT116
Concentration: 30 and 40 µM
Incubation Time: 48 h
Result: Significantly increased the cell population at the G0/G1 phase in a dosedependent manner.

Apoptosis Analysis[1]

Cell Line: HCT116
Concentration: 30 and 40 µM
Incubation Time: 72 h
Result: Increased the percentage of both early and late apoptotic cells.

Western Blot Analysis[1]

Cell Line: HCT116
Concentration: 30 μM
Incubation Time: 72 h
Result: Increased the expression levels of cleaved PARP, p27 and p53, and decreased the expression levels of cyclin D1 and CDK2.
Molecular Weight

322.48

Formula

C20H34O3
CAS No.
SMILES

C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C(C)(C(CC2)O)C)C[C@](CC3)([H])[C@@](O)(C4)CO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ent-Kaurane-3α,16β,17-triol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ent-Kaurane-3α,16β,17-triol130855-22-0ApoptosisHCT116PARPp27p53cyclin D1CDK2HepG2Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ent-Kaurane-3α,16β,17-triol
Cat. No.:
HY-N3825
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.