2. GPCR/G Protein
  3. Mas-related G-protein-coupled Receptor (MRGPR)
  4. EP-3945

EP-3945 is an agonist of Mas-related G protein-coupled receptor (MRGPR) with greater potency than the MRGPRD small molecule agonist β-Alanine (HY-N0230). MRGPR plays an important role in inflammatory itch and pain sensation. At the same time, MRGPR binds to Gq (MRGPRX2, MRGPRX4, MRGPRX1 are coupled to Gq; MRGPRX2, MRGPRD are coupled to Gi), and the EC50 of EP-3945 on Gq is 211.6 nM.

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EP-3945 Chemical Structure

EP-3945 Chemical Structure

CAS No. : 3057176-00-5

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Description

EP-3945 is an agonist of Mas-related G protein-coupled receptor (MRGPR) with greater potency than the MRGPRD small molecule agonist β-Alanine (HY-N0230). MRGPR plays an important role in inflammatory itch and pain sensation. At the same time, MRGPR binds to Gq (MRGPRX2, MRGPRX4, MRGPRX1 are coupled to Gq; MRGPRX2, MRGPRD are coupled to Gi), and the EC50 of EP-3945 on Gq is 211.6 nM.

Molecular Weight

418.49

Formula

C24H26N4O3
CAS No.
SMILES

O=C(C1(CC1)C2=CC=C(OC)C=C2)N(CC3)CCC3NC(NC4=O)=NC5=C4C=CC=C5
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EP-3945 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EP-39453057176-00-5EP3945EP 3945Mas-related G-protein-coupled Receptor (MRGPR)Inhibitorinhibitorinhibit

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