Ep300/CREBBP-IN-4

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Ep300/CREBBP-IN-4 (Example 56) is a potent Ep300 and CREBBP inhibitor with IC₅₀s of 0.024 and 0.064 μM, respectively. Ep300/CREBBP-IN-4 can be used for the research of cancer.

For research use only. We do not sell to patients.

Ep300/CREBBP-IN-4 Chemical Structure

CAS No. : 2259641-42-2

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Purity & Documentation
References
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Description

Ep300/CREBBP-IN-4 (Example 56) is a potent Ep300 and CREBBP inhibitor with IC₅₀s of 0.024 and 0.064 μM, respectively. Ep300/CREBBP-IN-4 can be used for the research of cancer^[1].

IC₅₀ & Target^[1]

EP300

0.024 μM (IC₅₀)

CREBBP

0.064 μM (IC₅₀)

In Vitro

Ep300/CREBBP-IN-4 (Example 56) inhibits intracellular H3K27Ac activity with an IC₅₀ of 0.020 μM^[1].
Ep300/CREBBP-IN-4 (38 nM-10 mM; 3 days) inhibits LK2 and TE-8 cell growth with GI₅₀s of 98.803 and 88.333 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	LK2 and TE-8 cells
Concentration:	38 nM-10 mM
Incubation Time:	3 days
Result:	Inhibited LK2 and TE-8 cell growth with GI₅₀s of 98.803 and 88.333 μM, respectively.

Molecular Weight

473.45

Formula

C₂₃H₂₂F₃N₅O₃

CAS No.

2259641-42-2

SMILES

O=C(N1[C@H](C[C@H](C1)F)C(NC2=CC=C(NN=C3)C3=N2)=O)C4(C5=CC=C(C=C5)OC)CC(F)(C4)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. NAITO Hiroyuki, et al. EP300 / CREBBP inhibitor. Patent JPWO2018235966A1.

Ep300/CREBBP-IN-4 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ep300/CREBBP-IN-42259641-42-2Histone AcetyltransferaseHATsHATH3K27AcLK2TE-8Inhibitorinhibitorinhibit

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