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  5. Eupenifeldin

Eupenifeldin is pentacyclic bistropolone isolated from cultures of Eupenicillium brefeldianum ATCC 74184. Eupenifeldin is cytotoxic against the HCT-116 cell line. Eupenifeldin has the potential for the research of leukemia.

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Eupenifeldin Chemical Structure

Eupenifeldin Chemical Structure

CAS No. : 151803-45-1

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Based on 1 publication(s) in Google Scholar

Eupenifeldin Related Antibodies

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Description

Eupenifeldin is pentacyclic bistropolone isolated from cultures of Eupenicillium brefeldianum ATCC 74184. Eupenifeldin is cytotoxic against the HCT-116 cell line. Eupenifeldin has the potential for the research of leukemia[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
30.6 nM
Compound: 4
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 26651221]
H4 IC50
130 nM
Compound: 4
Antiproliferative activity against human H4 cells after 48 hrs by MTT assay
Antiproliferative activity against human H4 cells after 48 hrs by MTT assay
[PMID: 26651221]
HCT-116 IC50
31.2 nM
Compound: 4
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 26651221]
HeLa IC50
8.2 nM
Compound: 4
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 26651221]
SH-SY5Y IC50
80 nM
Compound: 4
Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay
Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay
[PMID: 26651221]
T-24 IC50
12.5 nM
Compound: 4
Antiproliferative activity against human T24 cells after 48 hrs by MTT assay
Antiproliferative activity against human T24 cells after 48 hrs by MTT assay
[PMID: 26651221]
U-251 IC50
100 nM
Compound: 4
Antiproliferative activity against human U251 cells after 48 hrs by MTT assay
Antiproliferative activity against human U251 cells after 48 hrs by MTT assay
[PMID: 26651221]
Molecular Weight

548.67

Formula

C33H40O7
CAS No.
SMILES

OC1=CC2=C(C[C@@]3([C@@](C)([C@H](C[C@@]4(CC5=C(O[C@]4(C/C=C/C(C)(C3)C)C)C=C(C(C=C5C)=O)O)[H])O)O2)[H])C(C)=CC1=O
Structure Classification
Initial Source

Eupenicillium brefeldianum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Eupenifeldin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eupenifeldin151803-45-1OthersEupenicillium brefeldianumcytotoxicleukemiaInhibitorinhibitorinhibit

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