2. GPCR/G Protein
  3. LPL Receptor
  4. Ex26

Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach.

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Ex26 Chemical Structure

Ex26 Chemical Structure

CAS No. : 1233332-37-0

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Based on 1 publication(s) in Google Scholar

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Description

Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach[1].

IC50 & Target

IC50: 0.93 nM (S1P1)[1]
In Vitro

Ex26 (0-10 μM; 1 h) treatment shows excellent selectivity for S1P1 over other Sphingosine 1-phosphate receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ex26 Related Antibodies

Cell Viability Assay[1]

Cell Line: U2OS cells, and Chinese hamster ovary cells
Concentration: 0-10 μM
Incubation Time: 1 hour
Result: Confirmed a potent and selective antagonist of S1P1 (IC50=0.93 nM).
In Vivo

Ex26 (i.p.; 3 mg/kg; once daily; 3 d) treatment disrupts S1P1 signaling inhibiting the lymphocyte and thymocyte egress[1].
Ex26 (i.p.; 30 mg/kg; once daily; 15 d) treatment alleviates experimental autoimmune encephalomyelitis by S1P1 antagonism[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male C57Bl/6J mice[1]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection; 3 mg/kg; once daily; 3 days
Result: Induced lymphocyte sequestration at low doses, possessing an ED50 of 0.06 mg/kg after 2 hours treatment. Led to significant retention of T and B cells within the lymph nodes and significant decreases in T and B cells within the spleen.
Animal Model: Eight-week-old male C57Bl/6J mice induced with experimental autoimmune encephalomyelitis[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; 30 mg/kg; once daily; 15 days
Result: Inhibited both lymphocyte infiltration and destruction of the white matter in the spinal cord of mice euthanized at the end of the experiment.
Molecular Weight

494.98

Formula

C28H28ClFN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1(CC1)NC(C2=C(C=C(C=C2C)C3=CC(NC(C)C4=CC=C(C(C)=C4)Cl)=CC=C3F)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.0%

SDS (251 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References
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Ex26 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ex261233332-37-0S1P1-IN-Ex26Ex 26Ex-26LPL ReceptorLysophospholipid Receptorexperimental autoimmune encephalomyelitisEAEU2OSChinese hamster ovary cellsInhibitorinhibitorinhibit

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