FAK inhibitor 6

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Compound 26F not only optimized the effective inhibitory enzyme (ic₅₀= 28.2 nm), but also showed relatively less cytotoxicity (ic₅₀= 3.32 μ M) And induced MDA-MB-231 cell apoptosis in a dose-dependent manner, effectively blocking MDA-MB-231 cells in g0/g1 phase.

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FAK inhibitor 6 Chemical Structure

CAS No. : 2410056-27-6

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References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.27 μM Compound: 26f	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 31923858]
HK-2	IC₅₀	3.32 μM Compound: 26f	Cytotoxicity against human HK2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Cytotoxicity against human HK2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 31923858]
MDA-MB-231	IC₅₀	0.19 μM Compound: 26f	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 31923858]
U-87MG ATCC	IC₅₀	0.16 μM Compound: 26f	Antiproliferative activity against human U-87MG cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human U-87MG cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 31923858]

Molecular Weight

477.55

Formula

C₂₅H₂₄FN₅O₂S

CAS No.

2410056-27-6

SMILES

COC1=CC=CC=C1C2=CSC3=CN=C(N=C32)NC4=CC(F)=C(C=C4)C(NC5CCNCC5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang R,et al. Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors. Eur J Med Chem. 2020 Feb 15;188:112024. [Content Brief]

FAK inhibitor 6 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAK inhibitor 62410056-27-6FAK inhibitor6FAK inhibitor-6FAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseInhibitorinhibitorinhibit

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