2. Apoptosis
  3. Ferroptosis
  4. Ferroptosis-IN-8

Ferroptosis-IN-8 is a potent ferroptosis inhibitor with an EC50 of 40.49 nM. Ferroptosis-IN-8 effectively reduces lipid ROS levels in cells. Ferroptosis-IN-8 act as an antioxidant by capturing lipid radicals, leading to a reduction in the accumulation of harmful lipid peroxides and, ultimately, inhibiting ferroptosis.

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Ferroptosis-IN-8 Chemical Structure

Ferroptosis-IN-8 Chemical Structure

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Ferroptosis-IN-8 Related Antibodies

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Description

Ferroptosis-IN-8 is a potent ferroptosis inhibitor with an EC50 of 40.49 nM. Ferroptosis-IN-8 effectively reduces lipid ROS levels in cells. Ferroptosis-IN-8 act as an antioxidant by capturing lipid radicals, leading to a reduction in the accumulation of harmful lipid peroxides and, ultimately, inhibiting ferroptosis[1].

IC50 & Target

IC50: 40.49 nM (Ferroptosis)
In Vitro

Ferroptosis-IN-8 (Compound B4) (200 nM) effectively rescues HKC, HK-2, Khos, SW480, and HTR-8/SVneo cells from ferroptosis induced by RSL3 or FIN56[1].
Ferroptosis-IN-8 (Compound B4) (200 nM) againstes ferroptosis predominantly relies on their intrinsic antioxidative capacity, rather than classical signaling pathways including lipid oxidation metabolism[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis-IN-8 Related Antibodies

Cell Viability Assay[1]

Cell Line: HKC, HK-2, HT-1080, Khos, SW480, and HTR-8/SVneo cells treatment with RSL3 or FIN56
Concentration: 200 nM
Incubation Time: 24 h
Result: Effectively rescued HKC, HK-2, HT-1080, Khos, SW480, and HTR-8/SVneo cells from ferroptosis induced by RSL3 or FIN56.

Real Time qPCR[1]

Cell Line: HT-1080 cell
Concentration: 200 nM
Incubation Time:
Result: Didn't significantly affect the protein levels of key factors related to lipid metabolism (ACSL4, ALOX15, and COX2), glutathione metabolism pathways (GPX4, SLC7A11), and iron metabolism (DMT1, TFRC, and FTH1)
In Vivo

Ferroptosis-IN-8 (Compound B4) (10 mg/kg, twice, 1 h before ischemia onset, i.p.) alleviates tissue damage in a mouse model of renal ischemia-reperfusion injury[1].
Ferroptosis-IN-8 (Compound B4) (10 mg/kg, i.p.) alleviates acetaminophen induced acute liver injury in mice by inhibiting ferritin [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: acetaminophen-induced acute liver injury mice model[1].
Dosage: 10 mg/kg
Administration: intraperitoneal injection (i.p.)
Result: Attenuated the increased plasma ALT and AST levels induced by acetaminophen, effectively reduced the injury response induced by acetaminophen[1].
Animal Model: kidney ischemia−reperfusion injury mice model[1].
Dosage: 10 mg/kg, twice, 1 h before ischemia onset.
Administration: intraperitoneal injection (i.p.)
Result: Reduced the levels of creatinine and BUN and alleviated the increase in KIM-1 levels in the I/R model[1].
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Molecular Weight

285.30

Formula

C15H15N3O3
SMILES

NC1=C(C=CC=C1O)C(N/N=C/C2=CC=C(C=C2)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ferroptosis-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis-IN-8FerroptosisFerroptosis inhibitorsRSL3lipid ROS levelskidney (I/R) injuryacute liver injuryInhibitorinhibitorinhibit

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