2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR2/3-IN-2

FGFR2/3-IN-2 (compound 10) is an orally active FGFR2 and FGFR3 inhibitor. FGFR2/3-IN-2 inhibits FGFR2 and FGFR3 with IC50s of 3.7 nM and 31.2 nM (preincubation time 1 h), respectively. FGFR2/3-IN-2 spares FGFR1/4 and other kinases without causing diarrhea and serum phosphate elevation in vivo. FGFR2/3-IN-2 induces tumor stasis or regression in the SNU-16 gastric cancer model.

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FGFR2/3-IN-2 Chemical Structure

FGFR2/3-IN-2 Chemical Structure

CAS No. : 3025799-28-1

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FGFR2/3-IN-2 Related Antibodies

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Description

FGFR2/3-IN-2 (compound 10) is an orally active FGFR2 and FGFR3 inhibitor. FGFR2/3-IN-2 inhibits FGFR2 and FGFR3 with IC50s of 3.7 nM and 31.2 nM (preincubation time 1 h), respectively. FGFR2/3-IN-2 spares FGFR1/4 and other kinases without causing diarrhea and serum phosphate elevation in vivo. FGFR2/3-IN-2 induces tumor stasis or regression in the SNU-16 gastric cancer model[1].

IC50 & Target[1]

FGFR1

140 nM (IC50)

FGFR2

3.7 nM (IC50)

FGFR3

31.2 nM (IC50)

Molecular Weight

522.53

Formula

C29H23FN6O3
CAS No.
SMILES

CC1=NC(OC2=CC=C(C=C2)C3=C(N4C(C=NC(C)=C4)=C3C(N)=O)C5=CC=C(C=C5)NC(C(F)=C)=O)=NC=C1
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FGFR2/3-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

FGFR2/3-IN-23025799-28-1FGFRFibroblast growth factor receptormetabolic stabilitytumorgastric cancerInhibitorinhibitorinhibit

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