FGFR4-IN-11

Cat. No.: HY-147515: FAQs
Data Sheet Handling Instructions

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FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC₅₀ of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity.

For research use only. We do not sell to patients.

FGFR4-IN-11 Chemical Structure

CAS No. : 2396664-85-8

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

FGFR4

2.1 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	IC₅₀	26 nM Compound: 30	Inhibition of cell proliferation in human Huh-7 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay Inhibition of cell proliferation in human Huh-7 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay	[PMID: 35549181]
MDA-MB-453	IC₅₀	6.3 nM Compound: 30	Inhibition of cell proliferation in human MDA-MB-453 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay Inhibition of cell proliferation in human MDA-MB-453 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay	[PMID: 35549181]

Molecular Weight

527.57

Formula

C₂₉H₂₉N₅O₅

CAS No.

2396664-85-8

SMILES

COC1=CC(C(C2=CNC3=NC(NC4=C(C=C(C=C4)N5CCOCC5)NC(C=C)=O)=CC=C32)=O)=CC(OC)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhong Z, et al. Discovery of Novel 7-Azaindole Derivatives as Selective Covalent Fibroblast Growth Factor Receptor 4 Inhibitors for the Treatment of Hepatocellular Carcinoma. J Med Chem. 2022 May 26;65(10):7278-7295. [Content Brief]

FGFR4-IN-11 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR4-IN-112396664-85-8FGFRFibroblast growth factor receptorhepatocellular carcinomaHCCHuH-7MDA-MB-453breast cancerantitumor activityInhibitorinhibitorinhibit

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