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  4. Florbenazine

Florbenazine (AV-133) is a diagnostic imaging agent targeting the central nervous system monoamine transporter VMAT2, and its F-18 labeled form can be used for PET scanning. The biodistribution of [18F]Florbenazine in mice shows a high striatum/cerebellum ratio (0.48), which can be used for the diagnostic research of neurodegenerative diseases (including dementia with Lewy bodies and Parkinson's disease).

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Florbenazine Chemical Structure

Florbenazine Chemical Structure

CAS No. : 937245-42-6

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Florbenazine Related Antibodies

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Description

Florbenazine (AV-133) is a diagnostic imaging agent targeting the central nervous system monoamine transporter VMAT2, and its F-18 labeled form can be used for PET scanning. The biodistribution of [18F]Florbenazine in mice shows a high striatum/cerebellum ratio (0.48), which can be used for the diagnostic research of neurodegenerative diseases (including dementia with Lewy bodies and Parkinson's disease)[1].

IC50 & Target

VMAT2[1]
Molecular Weight

365.48

Formula

C21H32FNO3
CAS No.
SMILES

COC1=C(OCCCF)C=C2CCN(C[C@H]([C@@H](C3)O)CC(C)C)[C@@]3([H])C2=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Florbenazine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Florbenazine937245-42-6AV-133AV133AV 133Biochemical Assay ReagentsInhibitorinhibitorinhibit

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