Flt-3 Inhibitor III 

Flt-3 Inhibitor III is a potent and selective FLT3 kinase inhibitor with an ₅₀ of 50 nM. Flt-3 Inhibitor III shows less active against other kinases. Flt-3 Inhibitor III has anticancer effects^[1].

Flt-3 Inhibitor III (compound 4) also inhibits c-Kit, KDR, c-Abl, CDK1, c-Src and Tie-2 with IC₅₀ values of 0.26 µM, 0.91 µM, 1.2 µM, 2.1 µM, 2.8 µM, and 8.0 µM, respectively^[1].
Flt-3 Inhibitor III (compound 4) blocks the proliferation of BaF3-ITD, BaF3-D835/Y, and MV4:11 cells, with IC₅₀ values of 0.24 µM, 0.76 µM, and 0.052 µM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

365.49

C₂₁H₂₃N₃OS

852045-46-6

C1(NC2=CC=C(OCCN3CCCC3)C=C2)=NC=C(C4=CC=CC=C4)S1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pascal Furet, et al. Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents. J Med Chem. 2006 Jul 27;49(15):4451-4.  [Content Brief]