Fluorescent polyamine probe-1 

Fluorescent polyamine probe-1 (compound 15) is a linear polyamine probe with high uptake efficiency. Fluorescent polyamine probe-1 can be used for the research of transport system into cancer cells^[1].

Fluorescent polyamine probe-1 is accumulated rapidly in cancer cells (MCF-7), but not in non-tumorigenic cells (MCF-10A)^[1].
Fluorescent polyamine probe-1 (4 h) shows ten-fold higher uptake efficiency compared with branched probes in MCF-7 cells and the intracellular accumulation can be observed as early as 1 h after probe addition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

542.52

C₂₈H₄₅BF₂N₈

2678634-03-0

Solid

White to off-white

[F-][B+3]1([N]2=C(C)C=C(C)C2=C(CCCC3=CN(CCCNCCCCNCCCN)N=N3)C4=C(C)C=C(C)[N-]41)[F-]

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Vanhoutte R, et al. Clickable Polyamine Derivatives as Chemical Probes for the Polyamine Transport System. Chembiochem. 2018 May 4;19(9):907-911.  [Content Brief]