2. PROTAC
  3. PROTAC Linkers
  4. Fmoc-12-aminododecanoic acid

Fmoc-12-aminododecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

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Fmoc-12-aminododecanoic acid Chemical Structure

Fmoc-12-aminododecanoic acid Chemical Structure

CAS No. : 128917-74-8

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Fmoc-12-aminododecanoic acid Related Antibodies

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Description

Fmoc-12-aminododecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Molecular Weight

437.57

Formula

C27H35NO4
CAS No.
SMILES

O=C(O)CCCCCCCCCCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O
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Fmoc-12-aminododecanoic acid Related Classifications

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Keywords:

Fmoc-12-aminododecanoic acid128917-74-8PROTAC LinkersInhibitorinhibitorinhibit

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