FTI-277 TFA

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FTI-277 TFA is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 TFA can inhibit hepatitis delta virus (HDV) infection.

For research use only. We do not sell to patients.

FTI-277 TFA Chemical Structure

CAS No. : 1217447-06-7

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Other Forms of FTI-277 TFA:

FTI-277 Get quote

2 Publications Citing Use of MCE FTI-277 TFA

: FTI-277 TFA purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Nov 22;8(65):109135-109150. [Abstract]; MCF-7 cells are pretreated with the indicated chemical inhibitors for 30min, followed by 15 min treatment with RA (20 μM) + EPA (80 μM).Cell extracts are prepared and subjected to western blotting analysis.

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K-Ras H-Ras N-Ras Ras

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Description	FTI-277 TFA is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 TFA can inhibit hepatitis delta virus (HDV) infection.
Molecular Weight	561.64
Formula	C₂₄H₃₀F₃N₃O₅S₂
CAS No.	1217447-06-7
SMILES	OC(C(F)(F)F)=O.CSCC[C@@H](C(OC)=O)NC(C1=C(C2=CC=CC=C2)C=C(C=C1)NC[C@@H](N)CS)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct;152(4):404-11. [Content Brief] [2]. Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10(1):e0116633. [Content Brief] [3]. Virtanen SS, et al. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Cell Biol Int. 2010 Aug;34(8):815-26. [Content Brief]

FTI-277 TFA Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FTI-2771217447-06-7FTI277FTI 277Farnesyl TransferaseApoptosisRasFtaseInhibitorinhibitorinhibit

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