2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. GABAA receptor agent 5

GABAA receptor agent 5 (compound 018) is a potent γ-GABAAR antagonist with an Ki of 0.020 µM. GABAA receptor agent 5 shows γ-GABAAR antagonist activity with low cellular membrane permeability.

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GABAA receptor agent 5 Chemical Structure

GABAA receptor agent 5 Chemical Structure

CAS No. : 1808389-92-5

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GABAA receptor agent 5 Related Antibodies

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Description

GABAA receptor agent 5 (compound 018) is a potent γ-GABAAR antagonist with an Ki of 0.020 µM. GABAA receptor agent 5 shows γ-GABAAR antagonist activity with low cellular membrane permeability[1].

In Vitro

GABAA receptor agent 5 (compound 018) shows antagonist activity with IC50s of 0.24, 0.088, 0.068, 0.33, 0.79, 0.32, 0.079, 0.051 µM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GABAA receptor agent 5 Related Antibodies
Molecular Weight

383.51

Formula

C21H25N3O2S
CAS No.
SMILES

O=C(C1=CC=CS1)NC2=CC=CC(C(N3CCC4(CC3)CCNCC4)=O)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GABAA receptor agent 5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GABAA receptor agent 51808389-92-5GABAA receptor agent5GABAA receptor agent-5GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorHEK293 cellscellular membrane permeabilityLtk cellsInhibitorinhibitorinhibit

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GABAA receptor agent 5
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