2. Immunology/Inflammation
  3. Galectin
  4. Galectin-3-IN-3

Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC50 values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively.

For research use only. We do not sell to patients.

Galectin-3-IN-3 Chemical Structure

Galectin-3-IN-3 Chemical Structure

CAS No. : 2491661-50-6

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Galectin-3-IN-3 Related Antibodies

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Galectin-1 Galectin-3 Galectin-4 Galectin-8

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Description

Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC50 values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively[1].

IC50 & Target

hGal-3

11 nM (IC50)

mGal-3

84 nM (IC50)

hGal-1

2720 nM (IC50)

hGal-9

3530 nM (IC50)

In Vivo

Galectin-3-IN-3 (2 mg/kg; i.v.; single dose) exhibits low clearance rate (CL=8 mL/min/kg), high volume of distribution (Vss=1.8 L/kg), and good oral bioavailability (F=40%) in mice plasma[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

590.00

Formula

C25H22ClF2N7O4S
CAS No.
SMILES

CO[C@H]1[C@@H](O[C@@H]([C@@H]([C@@H]1N2C=C(N=N2)C3=C(C(F)=C(C=C3)Cl)F)O)CO)C4=NC(C)=NN4C5=CC6=C(N=CS6)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Galectin-3-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Galectin-3-IN-32491661-50-6GalectincancerInhibitorinhibitorinhibit

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Product Name:
Galectin-3-IN-3
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HY-163405
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