Galectin-3-IN-3

Cat. No.: HY-163405: FAQs
Data Sheet Handling Instructions

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Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC₅₀ values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively.

For research use only. We do not sell to patients.

Galectin-3-IN-3 Chemical Structure

CAS No. : 2491661-50-6

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Biological Activity
Purity & Documentation
References
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Description

Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC₅₀ values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively^[1].

IC₅₀ & Target

hGal-3

11 nM (IC₅₀)

mGal-3

84 nM (IC₅₀)

hGal-1

2720 nM (IC₅₀)

hGal-9

3530 nM (IC₅₀)

In Vivo

Galectin-3-IN-3 (2 mg/kg; i.v.; single dose) exhibits low clearance rate (CL=8 mL/min/kg), high volume of distribution (V_ss=1.8 L/kg), and good oral bioavailability (F=40%) in mice plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

590.00

Formula

C₂₅H₂₂ClF₂N₇O₄S

CAS No.

2491661-50-6

SMILES

CO[C@H]1[C@@H](O[C@@H]([C@@H]([C@@H]1N2C=C(N=N2)C3=C(C(F)=C(C=C3)Cl)F)O)CO)C4=NC(C)=NN4C5=CC6=C(N=CS6)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu C, et al. Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design. Bioorg Med Chem. 2024;101:117638. [Content Brief]

Galectin-3-IN-3 Related Classifications

Molarity Calculator
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Galectin-3-IN-32491661-50-6GalectincancerInhibitorinhibitorinhibit

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