2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Gancotamab

Gancotamab (MM-302) is a HER2-targeted antibody-liposomal Doxorubicin conjugate with antitumor activity. Gancotamab encapsulates Doxorubicin to facilitate its delivery to HER2-overexpressing tumor cells.

For research use only. We do not sell to patients.

CAS No. : 1509928-00-0

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Gancotamab Related Antibodies

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Description

Gancotamab (MM-302) is a HER2-targeted antibody-liposomal Doxorubicin conjugate with antitumor activity. Gancotamab encapsulates Doxorubicin to facilitate its delivery to HER2-overexpressing tumor cells[1].

Isotype

scFv-heavy-lambda
Species

Human
IC50 & Target[1]

HER2

 

In Vitro

Gancotamab (MM-302; 0.5 μM; 72 hours) increases cell death in BT474-M3 and NCI-N87 cells[1].
Gancotamab (MM-302; 1 μM; 2-24 h) activates the p-p53 level and has no effect on p-Akt signal in BT474-M3 and NCI-N87 cells[1].
Gancotamab (MM-302) is a HER2-targeted liposome encapsulating approximately 20,000 molecules of Doxorubicin in its core and 45 single-chain anti-HER2 antibodies (scFv) conjugated to its surface[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gancotamab Related Antibodies

Cell Viability Assay[1]

Cell Line: BT474-M3 and NCI-N87 cells
Concentration: 0.5 μM
Incubation Time: 72 hours
Result: Significantly reduced in vitro viability.

Western Blot Analysis[1]

Cell Line: BT474-M3 and NCI-N87 cells
Concentration: 1 μM
Incubation Time: 2 h, 8 h, and 24 h
Result: Increased the p-p53 level and had no effect on p-Akt signal.
In Vivo

Gancotamab (MM-302; 3 mg/kg; i.v.; every 7 days; for 3 doses) shows tumor growth inhibition and increases the expression of the DNA damage marker p-p53[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old female NCR/nu mice injected with NCI-N87 cells[1]
Dosage: 3 mg/kg
Administration: i.v.; every 7 days; for 3 doses
Result: Showed significantly antitumor activity.
Clinical Trial
CAS No.
SMILES

[Gancotamab]
Storage

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Format
  • scFv-heavy-lambda
Purity & Documentation
References
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Gancotamab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gancotamab1509928-00-0MM-302MM302MM 302EGFREpidermal growth factor receptorErbB-1HER1DNA damageantitumor activityp-p53DoxorubicinHER2-positive metastatic breast cancerInhibitorinhibitorinhibit

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