GBM CSCs-IN-1 

GBM CSCs-IN-1 (Compound (−)-20), a derivative of rocaglate, is a potent inhibitor of glioblastoma stem cells (GBM CSCs) with an EC₅₀ of 45 nM, functioning by targeting the RNA helicase DDX3. Furthermore, GBM CSCs-IN-1 is also capable of inducing apoptosis^[1].

633.51

C₂₈H₂₉BrN₂O₈S

COC1=C2C(O[C@]3(C4=CC=C(Br)C=C4)[C@@]2(O)[C@H](O)[C@H](C(NS(N(C)C)(=O)=O)=O)[C@H]3C5=CC=CC=C5)=CC(OC)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang Z, et al. Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells[J]. ACS Central Science, 2024.