Gemcitabine monophosphate disodium (Synonyms: Gemcitabine 5′-phosphate disodium)

Cat. No.: HY-108932A: FAQs
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Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles.

For research use only. We do not sell to patients.

Gemcitabine monophosphate disodium Chemical Structure

CAS No. : 1638288-31-9

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Other Forms of Gemcitabine monophosphate disodium:

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Description

In Vivo

Gemcitabine monophosphate (19.5 mg/kg, intravenous injection, every other day, four injections) combined with LCP loaded with VEGF siRNA and GMP shows anti-small cell lung cancer activity and induces apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer^[1]
Dosage:	19.5 mg/kg, every other day, four injections
Administration:	Intravenous injection (i.v.)
Result:	Induced tumor cell apoptosis to 30-40%, reduced tumor cell proliferation by 8 times, significantly reduced tumor microvessel density (MVD), and inhibited tumor mitosis.

Molecular Weight

387.14

Formula

C₉H₁₀F₂N₃Na₂O₇P

CAS No.

1638288-31-9

SMILES

O=P(O[Na])(O[Na])OC[C@@H]1[C@@H](O)C(F)(F)[C@H](N2C=CC(N)=NC2=O)O1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther. 2013 Aug;21(8):1559-69. [Content Brief]

[2]. Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611. [Content Brief]

Gemcitabine monophosphate disodium Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gemcitabine monophosphate disodium1638288-31-9Gemcitabine 5′-phosphate disodiumApoptosisnon-small–cell lung cancerNSCLCVEGF siRNACisplatinbladder cancerInhibitorinhibitorinhibit

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