2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Gemlapodect

Gemlapodect (RO554965) is an inhibitor of phosphodiesterase 10A (PDE10A). Gemlapodect can be used for researching schizophrenia.

For research use only. We do not sell to patients.

Gemlapodect Chemical Structure

Gemlapodect Chemical Structure

CAS No. : 1380329-87-2

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Gemlapodect Related Antibodies

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Description

Gemlapodect (RO554965) is an inhibitor of phosphodiesterase 10A (PDE10A). Gemlapodect can be used for researching schizophrenia[1].

IC50 & Target[1]

PDE10A

 

In Vivo

Gemlapodect (5-15 mg; p.o.; once daily for 6 weeks) significantly improves the work and life social functions of Childhood-Onset Fluency Disorder (COFD) patients and shows biosafety[2].
Gemlapodect (10 mg/kg; p.o.; single dose) shows nothing change in glucose tolerance of 9 weeks male SD rats[2].
Gemlapodect (0.3 mg/kg; p.o.; once daily for 8 days) induces a slight glucose tolerance improvement, no changes in fasting blood glucose, and decreases of fasting insulin in 10 weeks male SD rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male patients with COFD (18-50 years old)[2].
Dosage: 5-15 mg.
Administration: Oral gavage; once daily for 6 weeks.
Result: Improved the Stuttering, work, social life, family life and home responsibilities of COFD patients and showed biosafety.
Animal Model: 9 weeks or 10 weeks male SD rats[2].
Dosage: 0.3 mg/kg or 10 mg/kg.
Administration: Oral gavage; once daily for 1 or 8 days.
Result: Showed insignificantly change of glucose tolerance in healthy rats.
Molecular Weight

431.45

Formula

C22H21N7O3
CAS No.
SMILES

O=C(C1=C(C(N2CCOCC2)=O)C=NN1C)NC3=CC4=NC(C5=CC=CC=C5)=NN4C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Gemlapodect Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gemlapodect1380329-87-2RO554965RO 554965RO-554965Phosphodiesterase (PDE)SchizophreniaInhibitorinhibitorinhibit

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