ADORA3 - adenosine A3 receptor Gene

Rattus norvegicus

Also known as A3; TGPCR1

Gene ID: 100911796 | Gene type: protein coding

About ADORA3

Primary_assembly 2: 193,388,713-193,392,357 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 272 orthologues, 3 paralogues and is associated with 3 phenotypes.

Summary

Enables G protein-coupled Adenosine Receptor activity. Involved in G protein-coupled receptor signaling pathway; regulation of norepinephrine secretion; and regulation of synaptic vesicle exocytosis. Located in presynaptic membrane. Is active in Schaffer collateral - CA1 synapse. Orthologous to human ADORA3 (adenosine A3 receptor). [provided by Alliance of Genome Resources, Apr 2022]

ADORA3 Products(2)

mRNA	Protein	Name
NM_001302750.1	NP_001289679.1	adenosine receptor A3 isoform a
NM_001302751.1	NP_001289680.1	adenosine receptor A3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled adenosine receptor activity	IDA IDA: Inferred from direct assay	1323836	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12475223	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	8987783	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	8987783	RGD
involved in regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	16539684	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	8987783	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	8987783	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	14502093	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADORA3 Protein Structure

7tmA_Adenosine_R_A3

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

adenosine receptor A3

adenosine receptor A3-like

putative G-protein coupled receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00400	ADORA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00401	Adora3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00402	ADORA3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ADORA3	NCBI	NCBI:140

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