ACTR2 - actin related protein 2 Gene

Homo sapiens

Also known as ARP2

Gene ID: 10097 | Gene type: protein coding

About ACTR2

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:65,227,831-65,271,253 (from NCBI)

This gene has 4 transcripts (splice variants), 260 orthologues and 26 paralogues. Ubiquitous expression in appendix (RPKM 135.1), lymph node (RPKM 134.7) and 25 other tissues.

Summary

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ACTR2 Products(2)

mRNA	Protein	Name
NM_001005386.3	NP_001005386.1	actin-related protein 2 isoform a
NM_005722.4	NP_005713.1	actin-related protein 2 isoform b

ACTR2 Protein Structure

Actin

0
100
200
300
394 a.a.

Protein Preferred Names

Protein Names

actin-related protein 2

ARP2 actin related protein 2 homolog

Related Diseases

Diseases

Alias

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive	Autosomal Recessive Centronuclear Myopathy
CNM2	Centronuclear Myopathy 2
Ar-Cnm	Myotubular Myopathy, Autosomal Recessive
Autosomal Recessive Myotubular Myopathy	Centronuclear Myopathy Autosomal Recessive
Myopathy, Centronuclear, Type 2

Coronin-1a Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00230	ACTR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ACTR2	MGD	MGI:1913963
Canis familiaris	ACTR2	VGNC	VGNC:37554
Macaca mulatta	ACTR2	VGNC	VGNC:103782
Bos taurus	ACTR2	VGNC	VGNC:25586
Rattus norvegicus	ACTR2	RGD	RGD:1310826
Felis catus	ACTR2	VGNC	VGNC:59556

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