2. Gene
  3. CDH18 - cadherin 18 Gene

CDH18 - cadherin 18 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CDH14; CDH24; CDH14L

Gene ID: 1016 | Gene type: protein coding

About CDH18

Cytogenetic location: 5p14.3 Genomic coordinates (GRCh38): 5:19,471,296-20,575,713 (from NCBI)

This gene has 12 transcripts (splice variants), 256 orthologues and 33 paralogues. Biased expression in brain (RPKM 4.0), adrenal (RPKM 1.3) and 1 other tissue.

Summary

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) Cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I Cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

CDH18 Products(11)

mRNA Protein Name
NM_001167667.3 NP_001161139.1 cadherin-18 isoform 2 precursor
NM_001291956.3 NP_001278885.1 cadherin-18 isoform 1 preproprotein
NM_001291957.2 NP_001278886.1 cadherin-18 isoform 3 precursor
NM_001349556.2 NP_001336485.1 cadherin-18 isoform 1 preproprotein
NM_001349558.2 NP_001336487.1 cadherin-18 isoform 1 preproprotein
NM_001349559.2 NP_001336488.1 cadherin-18 isoform 1 preproprotein
NM_001349560.2 NP_001336489.1 cadherin-18 isoform 3 precursor
NM_001349561.2 NP_001336490.1 cadherin-18 isoform 2 precursor
NM_001349562.2 NP_001336491.1 cadherin-18 isoform 4
NM_001349563.2 NP_001336492.1 cadherin-18 isoform 4
NM_004934.5 NP_004925.1 cadherin-18 isoform 1 preproprotein

CDH18 Protein Structure

Cadherin

Cadherin: Cadherin domain (64 - 150)

Cadherin

Cadherin: Cadherin domain (164 - 258)

Cadherin

Cadherin: Cadherin domain (273 - 352)

Cadherin

Cadherin: Cadherin domain (388 - 479)

Cadherin

Cadherin: Cadherin domain (492 - 589)

Cadherin_C

Cadherin_C: Cadherin cytoplasmic region (640 - 783)

  • 0
  • 200
  • 400
  • 600
  • 790 a.a.
Protein Preferred Names Protein Names

cadherin-18

cadherin 18, type 2

Related Diseases

Diseases Alias
Craniofacial-Deafness-Hand Syndrome

CDHS

Craniofacial Deafness Hand Syndrome

Sommer-Young-Wee-Frye Syndrome

Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss

Craniofacial-Hearing Loss-Hand Syndrome
Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome

Eem Syndrome

Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy

EEMS

Ectodermal Dysplasia-Ectrodactyly-Macular Dystrophy Syndrome

Albrectsen-Svendsen Syndrome

Ohdo-Hirayama-Terawaki Syndrome

Dysplasia, Ectodermal, Ectrodactyly, And Macular Dystrophy
Epidural Abscess

Abscess Epidural
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02328 CDH18 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CDH18 VGNC VGNC:39026
Rattus norvegicus CDH18 RGD RGD:1305430
Macaca mulatta CDH18 VGNC VGNC:70811
Mus musculus CDH18 MGD MGI:1344366
Bos taurus CDH18 VGNC VGNC:27097
Felis catus CDH18 VGNC VGNC:60676
Others CDH18 NCBI