2. Gene
  3. ANAPC10 - anaphase promoting complex subunit 10 Gene

ANAPC10 - anaphase promoting complex subunit 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DOC1; APC10

Gene ID: 10393 | Gene type: protein coding

About ANAPC10

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:144,994,575-145,098,571 (from NCBI)

This gene has 18 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.0) and 25 other tissues.

Summary

ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein Ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]

ANAPC10 Products(9)

mRNA Protein Name
NM_001256706.2 NP_001243635.1 anaphase-promoting complex subunit 10 isoform 1
NM_001256707.2 NP_001243636.1 anaphase-promoting complex subunit 10 isoform 1
NM_001256708.2 NP_001243637.1 anaphase-promoting complex subunit 10 isoform 1
NM_001256709.2 NP_001243638.1 anaphase-promoting complex subunit 10 isoform 2
NM_001256710.2 NP_001243639.1 anaphase-promoting complex subunit 10 isoform 3
NM_001256711.2 NP_001243640.1 anaphase-promoting complex subunit 10 isoform 3
NM_001256712.2 NP_001243641.1 anaphase-promoting complex subunit 10 isoform 4
NM_001318367.2 NP_001305296.1 anaphase-promoting complex subunit 10 isoform 5
NM_014885.5 NP_055700.2 anaphase-promoting complex subunit 10 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
34595750 GOA
Biological Process GO Annotation Evidence Reference Source
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
18485873 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein branched polyubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
Cellular Component GO Annotation Evidence Reference Source
part of anaphase-promoting complex IDA
IDA: Inferred from direct assay
10318877 GOA
part of anaphase-promoting complex IPI
IPI: Inferred from physical interaction
27120157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANAPC10 Protein Structure

ANAPC10

ANAPC10: Anaphase-promoting complex, subunit 10 (APC10) (4 - 183)

  • 0
  • 100
  • 185 a.a.
Protein Preferred Names Protein Names

anaphase-promoting complex subunit 10

cyclosome subunit 10

Related Diseases

Diseases Alias
Auditory System Cancer

Ear Neoplasms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00678 ANAPC10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ANAPC10 VGNC VGNC:25880
Macaca mulatta ANAPC10 VGNC VGNC:69682
Felis catus ANAPC10 VGNC VGNC:78452
Rattus norvegicus ANAPC10 RGD RGD:1308936
Mus musculus ANAPC10 MGD MGI:1916249
Canis familiaris ANAPC10 VGNC VGNC:37845