Cysltr1 - cysteinyl leukotriene receptor 1 Gene

Rattus norvegicus

Also known as Cyslt1

Gene ID: 114099 | Gene type: protein coding

About Cysltr1

Primary_assembly X: 71,663,821-71,690,121 reverse strand.mRatBN7.2:CM026994.1

This gene has 2 transcripts (splice variants), 177 orthologues, 14 paralogues and is associated with 25 phenotypes. Biased expression in Lung (RPKM 3.4), Heart (RPKM 23.7) and 9 other tissues.

Summary

Enables Leukotriene Receptor activity. Involved in inflammatory response; positive regulation of angiogenesis; and positive regulation of vasoconstriction. Predicted to be integral component of plasma membrane. Used to study pulmonary hypertension. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in allergic disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl Leukotriene Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cysltr1 Products(1)

mRNA	Protein	Name
NM_053641.2	NP_446093.1	cysteinyl leukotriene receptor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables leukotriene receptor activity	IDA IDA: Inferred from direct assay	12418588	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	17910051	RGD
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	21105577	RGD
involved in positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	17910051	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	16331105	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cysltr1 Protein Structure

7tmA_CysLTR1

0
100
200
300
339 a.a.

Protein Preferred Names

Protein Names

cysteinyl leukotriene receptor 1

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13315	Montelukast sodium	Antagonist	99.84%	Yes
HY-13315A	Montelukast	Antagonist	99.94%	Yes
HY-13315B	Montelukast dicyclohexylamine	Antagonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13315S1	Montelukast-d6 sodium	Antagonist	≥96.0%	Unkown
HY-13315S	Montelukast-d6	Antagonist	/	Unkown
HY-RS03494	CYSLTR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03495	Cysltr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03496	Cysltr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cysltr1	NCBI	NCBI:10800

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