CGB1 - chorionic gonadotropin subunit beta 1 Gene

Homo sapiens

Gene ID: 114335 | Gene type: protein coding

About CGB1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,035,569-49,036,895 (from NCBI)

This gene has 2 transcripts (splice variants), 36 orthologues and 9 paralogues. Restricted expression toward placenta (RPKM 22.7).

Summary

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]

CGB1 Products(2)

mRNA	Protein	Name
NM_001382421.1	NP_001369350.1	choriogonadotropin subunit beta variant 1 isoform 2
NM_033377.2	NP_203695.2	choriogonadotropin subunit beta variant 1 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone activity	IMP IMP: Inferred from mutant phenotype	19523396	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CGB1 Protein Structure

Cys_knot

0
100
155 a.a.

Protein Preferred Names

Protein Names

choriogonadotropin subunit beta variant 1

chorionic gonadotropin beta subunit 1

Related Diseases

Diseases

Alias

Chorioangioma

Placental Hemangioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02579	CGB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CGB1	MGD	MGI:96782
Rattus norvegicus	CGB1	NCBI

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