2. Gene
  3. MAPK7 - mitogen-activated protein kinase 7 Gene

MAPK7 - mitogen-activated protein kinase 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Bmk1; Erk5; Prkm7

Gene ID: 114509 | Gene type: protein coding

About MAPK7

Primary_assembly 10: 46,170,167-46,176,267 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 193 orthologues, 21 paralogues and is associated with 8 phenotypes. Biased expression in Lung (RPKM 3.3), Testes (RPKM 29.4) and 9 other tissues.

Summary

Enables ATP binding activity and MAP kinase activity. Involved in ERK5 cascade and protein autophosphorylation. Located in nucleus. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

MAPK7 Products(1)

mRNA Protein Name
NM_001191547.1 NP_001178476.1 mitogen-activated protein kinase 7
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
8663194 RGD
enables MAP kinase activity IDA
IDA: Inferred from direct assay
8663194 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19103177 RGD
Biological Process GO Annotation Evidence Reference Source
involved in ERK5 cascade IMP
IMP: Inferred from mutant phenotype
11782488 RGD
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
11782488 RGD
involved in negative regulation of smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20724525 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
11782488 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
8663194 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK7 Protein Structure

STKc_ERK5

STKc_ERK5: cd07855 (48 - 383)

  • 0
  • 200
  • 400
  • 600
  • 812 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 7

BMK-1

BMK1 kinase

ERK-5

MAP kinase 7

MAPK 7

big MAP kinase 1

extracellular signal-regulated kinase 5

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148063 DB0614 98.80% Unkown
HY-148061 DB1113 99.28% Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-149412 MHJ-627 Inhibitor / Unkown
HY-RS08118 MAPK7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08119 Mapk7 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08120 MAPK7 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens MAPK7 NCBI NCBI:5598