2. Gene
  3. Aspa - aspartoacylase Gene

Aspa - aspartoacylase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Acy2; nur7; Acy-2

Gene ID: 11484 | Gene type: protein coding

About Aspa

Summary

This gene encodes an Enzyme that deacteylates N-acetyl-L-aspartic acid (NAA) in the brain to yield acetate and L-aspartate. In humans, alterations in neuronal NAA concentration are associated with many neurodegenerative diseases (decrease associated with epilepsy, multiple sclerosis, myotrophic lateral sclerosis, and Alzheimer's disease; increase associated with Canavan disease). In mouse, mutations in this gene, which cause accumulation of NAA, result in demyelination and spongy degeneration in the CNS and serve as a pathophysiological model for Canavan disease. [provided by RefSeq, Dec 2012]

Aspa Products(1)

mRNA Protein Name
NM_023113.5 NP_075602.2 aspartoacylase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables aspartoacylase activity IDA
IDA: Inferred from direct assay
12706335 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22284616 MGI
Biological Process GO Annotation Evidence Reference Source
involved in acetate metabolic process IGI
IGI: Inferred from genetic interaction
28077719 MGI
involved in aspartate metabolic process IGI
IGI: Inferred from genetic interaction
28077719 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cytosol IDA
IDA: Inferred from direct assay
12706335 MGI
located in cytosol IDA
IDA: Inferred from direct assay
22284616 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aspartoacylase

aminoacylase-2

aspartoacylase (aminoacylase) 2

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148089 Eplontersen Inhibitor / Unkown
HY-B1680 Lithium citrate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132579 Tominersen 94.13% Phase 3
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N6246 Asperulosidic Acid Inhibitor 99.72% Unkown
HY-RS01099 ASPA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aspa NCBI NCBI:443
Macaca fascicularis Aspa NCBI NCBI:102137549
Susscrofa domestica Aspa NCBI
Rattus norvegicus Aspa NCBI NCBI:79251