C1QTNF1 - C1q and TNF related 1 Gene

Homo sapiens

Also known as GIP; CTRP1; ZSIG37

Gene ID: 114897 | Gene type: protein coding

About C1QTNF1

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,022,934-79,049,788 (from NCBI)

This gene has 12 transcripts (splice variants), 160 orthologues and 23 paralogues. Broad expression in fat (RPKM 33.8), placenta (RPKM 15.4) and 21 other tissues.

Summary

Enables collagen binding activity. Involved in several processes, including negative regulation of platelet aggregation; positive regulation of aldosterone secretion; and positive regulation of cytosolic calcium ion concentration. Located in extracellular space. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

C1QTNF1 Products(4)

mRNA	Protein	Name
NM_030968.5	NP_112230.1	complement C1q tumor necrosis factor-related protein 1 isoform 1 precursor
NM_153372.3	NP_699203.1	complement C1q tumor necrosis factor-related protein 1 isoform 1 precursor
NM_198593.4	NP_940995.1	complement C1q tumor necrosis factor-related protein 1 isoform 1 precursor
NM_198594.4	NP_940996.1	complement C1q tumor necrosis factor-related protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables collagen binding	IDA IDA: Inferred from direct assay	16195328	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12409230	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of platelet activation	IDA IDA: Inferred from direct assay	16195328	GOA
involved in negative regulation of platelet aggregation	IDA IDA: Inferred from direct assay	16195328	GOA
involved in positive regulation of aldosterone secretion	IDA IDA: Inferred from direct assay	18171693	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	18171693	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18171693	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18171693	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12409230	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QTNF1 Protein Structure

Collagen

C1q

0
100
200
281 a.a.

Protein Preferred Names

Protein Names

complement C1q tumor necrosis factor-related protein 1

C1q and tumor necrosis factor related protein 1

Recombinant C1QTNF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7693	C1QTNF1/CTRP1 Protein, Human (HEK293, His)	Q9BXJ1-1 (R26-P281)	≥95%

Related Diseases

Diseases

Alias

Granulomatous Disease, Chronic, Autosomal Recessive, 2

Chronic Granulomatous Disease Due To Deficiency Of Ncf-2	CGD2
Ncf2 Deficiency	P67-Phox Deficiency
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii	Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii
Granulomatous Disease, Chronic, Due To Ncf2 Deficiency	Neutrophil Cytosol Factor 2 Deficiency
Chronic Granulomatous Disease 2, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 2
Cdg2	Deficiency Of Ncf2
Deficiency Of P67-Phox	Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii
Deficiency Of Neutrophil Cytosol Factor 2	Avellino Corneal Dystrophy

Chorioangioma

Placental Hemangioma

Late-Onset Retinal Degeneration

LORD	Retinal Degeneration, Late-Onset, Autosomal Dominant
Autosomal Dominant Late-Onset Retinal Degeneration	Pigmentary Retinopathy
Retinal Degeneration, Late-Onset	Retinitis Pigmentosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01726	C1QTNF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	C1QTNF1	RGD	RGD:1359204
Mus musculus	C1QTNF1	MGD	MGI:1919254
Canis familiaris	C1QTNF1	VGNC	VGNC:51925
Macaca mulatta	C1QTNF1	VGNC	VGNC:70311
Felis catus	C1QTNF1	VGNC	VGNC:60221
Bos taurus	C1QTNF1	VGNC	VGNC:26622
Others	C1QTNF1	NCBI

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