2. Gene
  3. Adora3 - adenosine A3 receptor Gene

Adora3 - adenosine A3 receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as A3R; A3AR; AA3R; ARA3; Gpcr2

Gene ID: 11542 | Gene type: protein coding

About Adora3

Chromosome 3: 105,778,174-105,816,242 forward strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 272 orthologues, 3 paralogues and is associated with 15 phenotypes. Biased expression in testis adult (RPKM 3.8), mammary gland adult (RPKM 1.) and 14 other tissues.

Summary

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. This gene shares its 3' terminal exon with a transcript variant from overlapping GeneID:69296, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]

Adora3 Products(1)

mRNA Protein Name
NM_009631.4 NP_033761.2 adenosine receptor A3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled adenosine receptor activity IDA
IDA: Inferred from direct assay
12817016 MGI
enables G protein-coupled adenosine receptor activity IMP
IMP: Inferred from mutant phenotype
10660615 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within G protein-coupled adenosine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12817016 MGI
acts upstream of calcium-mediated signaling IDA
IDA: Inferred from direct assay
12817016 MGI
acts upstream of calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
12817016 MGI
acts upstream of or within histamine secretion by mast cell IDA
IDA: Inferred from direct assay
12817016 MGI
acts upstream of or within histamine secretion by mast cell IMP
IMP: Inferred from mutant phenotype
12817016 MGI
acts upstream of mast cell degranulation IDA
IDA: Inferred from direct assay
12817016 MGI
acts upstream of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
12817016 MGI
acts upstream of mucus secretion IGI
IGI: Inferred from genetic interaction
15240734 MGI
acts upstream of mucus secretion IMP
IMP: Inferred from mutant phenotype
15240734 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
12817016 MGI
acts upstream of or within positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
12817016 MGI
acts upstream of or within positive regulation of calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
12817016 MGI
acts upstream of or within positive regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
15240734 MGI
acts upstream of or within positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
15240734 MGI
acts upstream of or within positive regulation of leukocyte migration IGI
IGI: Inferred from genetic interaction
15240734 MGI
acts upstream of or within positive regulation of leukocyte migration IMP
IMP: Inferred from mutant phenotype
15240734 MGI
acts upstream of or within positive regulation of mast cell degranulation IDA
IDA: Inferred from direct assay
12817016 MGI
acts upstream of or within positive regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
12817016 MGI
acts upstream of or within positive regulation of mucus secretion IGI
IGI: Inferred from genetic interaction
15240734 MGI
acts upstream of or within positive regulation of mucus secretion IMP
IMP: Inferred from mutant phenotype
15240734 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
12817016 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
24754634 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12817016 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
10660615 MGI
is active in synapse IDA
IDA: Inferred from direct assay
24754634 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adora3 Protein Structure

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (13 - 293)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (14 - 40)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (47 - 74)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (83 - 113)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (127 - 145)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (174 - 204)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (223 - 253)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (261 - 286)

  • 0
  • 100
  • 200
  • 300
  • 319 a.a.
Protein Preferred Names Protein Names

adenosine receptor A3

G-protein coupled receptor 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00400 ADORA3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00401 Adora3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00402 ADORA3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adora3 NCBI NCBI:140