Cdk5r1 - cyclin-dependent kinase 5 regulatory subunit 1 Gene

Rattus norvegicus

Also known as p35; Cdk5r

Gene ID: 116671 | Gene type: protein coding

About Cdk5r1

Summary

Enables several functions, including cadherin binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and Ephrin Receptor binding activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; nervous system development; and regulation of synaptic vesicle cycle. Located in several cellular components, including dendritic spine; growth cone; and postsynaptic density. Part of protein kinase 5 complex. Is active in presynapse. Biomarker of hypothyroidism and trigeminal neuralgia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5r1 Products(1)

mRNA	Protein	Name
NM_053891.2	NP_446343.1	cyclin-dependent kinase 5 activator 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cadherin binding	IDA IDA: Inferred from direct assay	10753743	RGD
enables calcium ion binding	IDA IDA: Inferred from direct assay	12223541	RGD
enables cyclin-dependent protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	8662984	RGD
enables cyclin-dependent protein serine/threonine kinase activator activity	IGI IGI: Inferred from genetic interaction	17517623	RGD
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	17143272	RGD
enables kinase activity	IDA IDA: Inferred from direct assay	8846918	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8846918	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25665755	RGD
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	8662984	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled acetylcholine receptor signaling pathway	IDA IDA: Inferred from direct assay	11276227	RGD
involved in embryo development ending in birth or egg hatching	IDA IDA: Inferred from direct assay	11276227	RGD
involved in ionotropic glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	12223541	RGD
involved in neuron differentiation	IDA IDA: Inferred from direct assay	8846918	RGD
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	8846918	RGD
involved in positive regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	16192386	RGD
involved in regulation of synaptic vesicle cycle	IDA IDA: Inferred from direct assay	24254883	RGD
involved in regulation of synaptic vesicle cycle	IEP IEP: Inferred from expression pattern	24254883	RGD
involved in regulation of synaptic vesicle cycle	IMP IMP: Inferred from mutant phenotype	24254883	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	8846918	RGD
located in contractile muscle fiber	IDA IDA: Inferred from direct assay	11276227	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	11276227	RGD
located in dendrite	IDA IDA: Inferred from direct assay	8846918	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	12223541	RGD
located in growth cone	IDA IDA: Inferred from direct assay	8846918	RGD
located in membrane	IDA IDA: Inferred from direct assay	11276227	RGD
located in neuromuscular junction	IDA IDA: Inferred from direct assay	11276227	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8846918	RGD
located in nucleus	IDA IDA: Inferred from direct assay	16192386	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	17143272	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	24254883	RGD
part of protein kinase 5 complex	IDA IDA: Inferred from direct assay	8662984	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cyclin-dependent kinase 5 activator 1

CDK5 activator 1	TPKII regulatory subunit
p23	tau protein kinase II 23 kDa subunit

Cdk5r1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cdk5r1	P61810	Cdk5	Rattus norvegicus	Q03114	Anti Bait CoIP	17036052
Intra	Cdk5r1	P61810	Cdk5	Rattus norvegicus	Q03114	Anti Bait CoIP	17341134
Intra	Cdk5r1	P61810	Fzr1	Rattus norvegicus	B1WCA1	Protein Kinase Assay	18818692
Intra	Cdk5r1	P61810	Fzr1	Rattus norvegicus	B1WCA1	Anti Bait CoIP	18818692

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02387	CDK5R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdk5r1	NCBI	NCBI:8851

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