CDK5R1 - cyclin dependent kinase 5 regulatory subunit 1 Gene

Homo sapiens

Also known as p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a

Gene ID: 8851 | Gene type: protein coding

About CDK5R1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:32,486,993-32,491,253 (from NCBI)

This gene has 3 transcripts (splice variants), 289 orthologues and 1 paralogue. Biased expression in brain (RPKM 36.6), lymph node (RPKM 6.6) and 5 other tissues.

Summary

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]

CDK5R1 Products(1)

mRNA	Protein	Name
NM_003885.3	NP_003876.1	cyclin-dependent kinase 5 activator 1

CDK5R1 Protein Structure

CDK5_activator

0
100
200
307 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 5 activator 1

CDK5 activator 1

Related Diseases

Diseases

Alias

Alzheimer Disease 12

Ad12	Alzheimer'S Disease 12
Alzheimer Disease, Familial, 12	Alzheimer Disease Familial 12

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02387	CDK5R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CDK5R1	VGNC	VGNC:70981
Canis familiaris	CDK5R1	VGNC	VGNC:39055
Mus musculus	CDK5R1	MGD	MGI:101764
Bos taurus	CDK5R1	VGNC	VGNC:27128
Rattus norvegicus	CDK5R1	RGD	RGD:629472
Felis catus	CDK5R1	VGNC	VGNC:60701

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