Mta1 - metastasis associated 1 Gene

Mus musculus

Gene ID: 116870 | Gene type: protein coding

About Mta1

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coactivator activity. Involved in several processes, including circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and locomotor rhythm. Located in cytoplasm and nucleus. Part of NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and long bone epiphysis. Orthologous to human MTA1 (metastasis associated 1). [provided by Alliance of Genome Resources, Apr 2022]

Mta1 Products(6)

mRNA	Protein	Name
NM_001346696.1	NP_001333625.1	metastasis-associated protein MTA1 isoform 2
NM_001364620.1	NP_001351549.1	metastasis-associated protein MTA1 isoform 3
NM_001364621.1	NP_001351550.1	metastasis-associated protein MTA1 isoform 4
NM_001364622.1	NP_001351551.1	metastasis-associated protein MTA1 isoform 5
NM_001364623.1	NP_001351552.1	metastasis-associated protein MTA1 isoform 6
NM_054081.2	NP_473422.2	metastasis-associated protein MTA1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24089055	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11836251	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	24089055	MGI
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	21965678	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24089055	MGI
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	19805145	MGI
involved in entrainment of circadian clock by photoperiod	IMP IMP: Inferred from mutant phenotype	24089055	MGI
involved in locomotor rhythm	IMP IMP: Inferred from mutant phenotype	24089055	MGI
involved in response to ionizing radiation	IDA IDA: Inferred from direct assay	19805145	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of NuRD complex	IPI IPI: Inferred from physical interaction	16462733	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15978591	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11483358	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

metastasis-associated protein MTA1

Mta1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mta1	Q8K4B0	Six3	Mus musculus	Q62233	Anti Bait CoIP	17666527

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08746	MTA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mta1	NCBI	NCBI:9112

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