2. Gene
  3. MTA1 - metastasis associated 1 Gene

MTA1 - metastasis associated 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 9112 | Gene type: protein coding

About MTA1

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,419,827-105,470,729 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 14.9), spleen (RPKM 9.4) and 25 other tissues.

Summary

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

MTA1 Products(4)

mRNA Protein Name
NM_001203258.2 NP_001190187.1 metastasis-associated protein MTA1 isoform MTA1s
NM_001411061.1 NP_001397990.1 metastasis-associated protein MTA1 isoform 3
NM_001411062.1 NP_001397991.1 metastasis-associated protein MTA1 isoform 4
NM_004689.4 NP_004680.2 metastasis-associated protein MTA1 isoform MTA1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21965678 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
22926524 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16511565 GOA
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
21965678 GOA
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
21965678 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
9790534 GOA
involved in double-strand break repair IMP
IMP: Inferred from mutant phenotype
19805145 GOA
involved in negative regulation of gene expression, epigenetic IMP
IMP: Inferred from mutant phenotype
24413532 GOA
involved in positive regulation of protein autoubiquitination IDA
IDA: Inferred from direct assay
19805145 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
19805145 GOA
involved in response to ionizing radiation IDA
IDA: Inferred from direct assay
19805145 GOA
Cellular Component GO Annotation Evidence Reference Source
part of NuRD complex IDA
IDA: Inferred from direct assay
22926524 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
24970816 GOA
located in microtubule IDA
IDA: Inferred from direct assay
24970816 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
24970816 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21965678 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTA1 Protein Structure

BAH

BAH: BAH domain (4 - 164)

ELM2

ELM2: ELM2 domain (167 - 220)

GATA

GATA: GATA zinc finger (393 - 429)

  • 0
  • 200
  • 400
  • 600
  • 715 a.a.
Protein Preferred Names Protein Names

metastasis-associated protein MTA1

metastasis associated gene 1 protein

MTA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MTA1 Q13330 KRT40 Homo sapiens Q6A162
Y2H Array
31515488
Intra MTA1 Q13330 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra MTA1 Q13330 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra MTA1 Q13330 SH3GL1 Homo sapiens Q6FGM0
Y2H Prey Pooling
25416956
Intra MTA1 Q13330 SH3GL1 Homo sapiens Q6FGM0
Y2H Array
25416956
Intra MTA1 Q13330 MAGEA11 Homo sapiens P43364-2
Validated Y2H
25416956
Intra MTA1 Q13330 MAGEA11 Homo sapiens P43364-2
Y2H Array
25416956
Intra MTA1 Q13330 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra MTA1 Q13330 HDAC2 Homo sapiens Q92769
Anti Tag CoIP
18451879
Intra MTA1 Q13330 HDAC2 Homo sapiens Q92769
Anti Tag CoIP
26028330
Intra MTA1 Q13330 HDAC1 Homo sapiens Q13547
Lumier
29997244
Intra MTA1 Q13330 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
26028330
Intra MTA1 Q13330 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
16511565
Intra MTA1 Q13330 HDAC1 Homo sapiens Q13547
CH-IP
26028330
Intra MTA1 Q13330 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
18451879
Intra MTA1 Q13330 KPNA3 Homo sapiens O00505
Validated Y2H
25416956
Intra MTA1 Q13330 KPNA3 Homo sapiens O00505
Y2H Prey Pooling
25416956
Intra MTA1 Q13330 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra MTA1 Q13330 KPNA4 Homo sapiens O00629
Y2H Array
32296183
Intra MTA1 Q13330 KPNA4 Homo sapiens O00629
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 HIF1A Homo sapiens Q16665
Anti Tag CoIP
16511565
Intra MTA1 Q13330 HIF1A Homo sapiens Q16665
Imaging
16511565
Intra MTA1 Q13330 HIF1A Homo sapiens Q16665
Anti Bait CoIP
16511565
Intra MTA1 Q13330 RBBP4 Homo sapiens Q09028
Y2H Prey Pooling
25416956
Intra MTA1 Q13330 RBBP4 Homo sapiens Q09028
Anti Tag CoIP
33961781
Intra MTA1 Q13330 SH3GL1 Homo sapiens Q99961
Validated Y2H
32296183
Intra MTA1 Q13330 SH3GL1 Homo sapiens Q99961
Y2H Array
32296183
Intra MTA1 Q13330 SH3GL1 Homo sapiens Q99961
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 ZEB2 Homo sapiens O60315
Anti Tag CoIP
26028330
Intra MTA1 Q13330 ZEB2 Homo sapiens O60315
Pull Down
26028330
Intra MTA1 Q13330 ZEB2 Homo sapiens O60315
CH-IP
26028330
Intra MTA1 Q13330 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra MTA1 Q13330 KHDRBS2 Homo sapiens Q5VWX1
Y2H Array
25416956
Intra MTA1 Q13330 EHMT2 Homo sapiens Q96KQ7
Anti Bait CoIP
26028330
Intra MTA1 Q13330 EHMT2 Homo sapiens Q96KQ7
Pull Down
26028330
Intra MTA1 Q13330 EHMT2 Homo sapiens Q96KQ7
Anti Tag CoIP
26028330
Intra MTA1 Q13330 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
Intra MTA1 Q13330 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra MTA1 Q13330 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra MTA1 Q13330 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 JUN Homo sapiens P05412
Pull Down
21555589
Intra MTA1 Q13330 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra MTA1 Q13330 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra MTA1 Q13330 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra MTA1 Q13330 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra MTA1 Q13330 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 PLEKHG4 Homo sapiens Q58EX7
Validated Y2H
32296183
Intra MTA1 Q13330 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microphthalmia, Isolated 1

Isolated Microphthalmia 1

MCOP1

Mcop

Anophthalmia, Clinical, Isolated

Microphthalmos, Autosomal Recessive
Adenocarcinoma

Adenocarcinomas

Adenoacanthoma Of Unspecified Site

Adenocarcinoid Of Unspecified Site

Adenocarcinoid Tumour Of Unspecified Site

Adenocarcinoma And Carcinoid Combined Of Unspecified Site

Adenocarcinoma Nos
Developmental And Epileptic Encephalopathy 44

DEE44

Epileptic Encephalopathy, Early Infantile, 44

Eiee44

Developmental And Epileptic Encephalopathy, 44

Early Infantile Epileptic Encephalopathy 44

Encephalopathy, Epileptic, Early Infantile, Type 44
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08746 MTA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MTA1 VGNC VGNC:68334
Rattus norvegicus MTA1 RGD RGD:621018
Macaca mulatta MTA1 VGNC VGNC:74942
Mus musculus MTA1 MGD MGI:2150037
Canis familiaris MTA1 VGNC VGNC:43456