Six3 - sine oculis-related homeobox 3 Gene

Mus musculus

Also known as Six3a; Six3b; Six3beta; Six3alpha; E130112M24Rik

Gene ID: 20473 | Gene type: protein coding

About Six3

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and transcription corepressor binding activity. Involved in several processes, including animal organ development; lens fiber cell apoptotic process; and neuroblast migration. Acts upstream of or within several processes, including animal organ development; circadian behavior; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including embryo ectoderm; limb; maxillary process; nervous system; and sensory organ. Used to study holoprosencephaly 2. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Orthologous to human SIX3 (SIX homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Six3 Products(1)

mRNA	Protein	Name
NM_011381.4	NP_035511.2	homeobox protein SIX3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12050133	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17066077	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12569128	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17066077	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	17666527	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12050133	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8814301	MGI
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	17666527	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic process involved in development	IMP IMP: Inferred from mutant phenotype	18694563	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	12569128	MGI
acts upstream of or within camera-type eye development	IGI IGI: Inferred from genetic interaction	12072567	MGI
involved in cell proliferation in forebrain	IMP IMP: Inferred from mutant phenotype	18694563	MGI
acts upstream of or within circadian behavior	IMP IMP: Inferred from mutant phenotype	21525287	MGI
acts upstream of or within diencephalon development	IGI IGI: Inferred from genetic interaction	18094027	MGI
involved in epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	22071110	MGI
acts upstream of or within eye development	IDA IDA: Inferred from direct assay	12050133	MGI
acts upstream of or within forebrain anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	18094027	MGI
acts upstream of or within forebrain anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	18094027	MGI
acts upstream of or within gonad development	IGI IGI: Inferred from genetic interaction	18775421	MGI
involved in lens development in camera-type eye	IDA IDA: Inferred from direct assay	11139622	MGI
involved in lens fiber cell apoptotic process	IDA IDA: Inferred from direct assay	12072567	MGI
involved in lens fiber cell differentiation	IDA IDA: Inferred from direct assay	12072567	MGI
acts upstream of or within lens induction in camera-type eye	IMP IMP: Inferred from mutant phenotype	17066077	MGI
acts upstream of or within multicellular organism growth	IGI IGI: Inferred from genetic interaction	18775421	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12050133	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11139622	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	12569128	MGI
involved in negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	17576749	MGI
involved in neuroblast differentiation	IMP IMP: Inferred from mutant phenotype	22071110	MGI
involved in neuroblast migration	IMP IMP: Inferred from mutant phenotype	22071110	MGI
involved in optic vesicle morphogenesis	IDA IDA: Inferred from direct assay	11458394	MGI
acts upstream of or within pituitary gland development	IGI IGI: Inferred from genetic interaction	18775421	MGI
involved in pituitary gland development	IMP IMP: Inferred from mutant phenotype	18775421	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17066077	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17066077	MGI
acts upstream of or within protein import into nucleus	IDA IDA: Inferred from direct assay	16024294	MGI
involved in proximal/distal axis specification	IDA IDA: Inferred from direct assay	12163408	MGI
involved in regulation of cell cycle phase transition	IDA IDA: Inferred from direct assay	17576749	MGI
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18775421	MGI
involved in regulation of neural precursor cell proliferation	IDA IDA: Inferred from direct assay	17576749	MGI
involved in regulation of neural retina development	IMP IMP: Inferred from mutant phenotype	20890044	MGI
involved in regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	22071110	MGI
acts upstream of or within telencephalon development	IMP IMP: Inferred from mutant phenotype	18094027	MGI
involved in telencephalon development	IMP IMP: Inferred from mutant phenotype	18694563	MGI
involved in telencephalon regionalization	IMP IMP: Inferred from mutant phenotype	18694563	MGI
acts upstream of or within thyroid gland development	IGI IGI: Inferred from genetic interaction	18775421	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	8814301	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein SIX3

sine oculis homeobox homolog 3

sine oculis-related homeobox 3 homolog

Six3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Six3	Q62233	Mta1	Mus musculus	Q8K4B0	Pull Down	17666527
Intra	Six3	Q62233	Hdac2	Mus musculus	P70288	Pull Down	17666527
Intra	Six3	Q62233	Hdac2	Mus musculus	P70288	Anti Bait CoIP	17666527
Intra	Six3	Q62233	Tle5	Mus musculus	P63002	Y2H	12050133
Cross	Six3	Q62233	gro	Drosophila melanogaster	P16371	Pull Down	12050133

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12960	SIX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Six3	NCBI	NCBI:6496

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