2. Gene
  3. TRIM6 - tripartite motif containing 6 Gene

TRIM6 - tripartite motif containing 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RNF89

Gene ID: 117854 | Gene type: protein coding

About TRIM6

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:5,596,111-5,612,952 (from NCBI)

This gene has 12 transcripts (splice variants), 76 orthologues and 80 paralogues. Broad expression in kidney (RPKM 10.6), testis (RPKM 6.4) and 15 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

TRIM6 Products(4)

mRNA Protein Name
NM_001003818.3 NP_001003818.1 tripartite motif-containing protein 6 isoform 1
NM_001198644.2 NP_001185573.1 tripartite motif-containing protein 6 isoform 3
NM_001198645.2 NP_001185574.1 tripartite motif-containing protein 6 isoform 3
NM_058166.5 NP_477514.1 tripartite motif-containing protein 6 isoform 2

TRIM6 Protein Structure

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (15 - 59)

zf-B_box

zf-B_box: B-box zinc finger (95 - 130)

SPRY

SPRY: SPRY domain (352 - 481)

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  • 488 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 6

RING finger protein 89

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15060 TRIM6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRIM6 VGNC VGNC:81100
Mus musculus TRIM6 MGD MGI:2137352
Rattus norvegicus TRIM6 RGD RGD:1310896
Macaca mulatta TRIM6 VGNC VGNC:110583
Others TRIM6 NCBI