2. Gene
  3. Serping1 - serine (or cysteine) peptidase inhibitor, clade G, member 1 Gene

Serping1 - serine (or cysteine) peptidase inhibitor, clade G, member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as C1nh; C1INH

Gene ID: 12258 | Gene type: protein coding

About Serping1

Summary

Enables complement binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of complement activation, lectin pathway and negative regulation of endopeptidase activity. Predicted to act upstream of or within several processes, including complement activation, classical pathway; fibrinolysis; and negative regulation of peptidase activity. Located in extracellular space. Is expressed in several structures, including genitourinary system; neural ectoderm; notochord; pancreas mesenchyme; and visceral pericardium. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1). [provided by Alliance of Genome Resources, Apr 2022]

Serping1 Products(1)

mRNA Protein Name
NM_009776.3 NP_033906.2 plasma protease C1 inhibitor precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables complement binding IPI
IPI: Inferred from physical interaction
9652403 MGI
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
9199246 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
9652403 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plasma protease C1 inhibitor

C1 Inh

C1 esterase inhibitor

C1 inhibitor

C1-inhibiting factor

complement component 1 inhibitor

serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1

serine (or cysteine) proteinase inhibitor, clade G, member 1

serpin G1

Recombinant Serping1 Proteins

Cat. No. Product Name Accession Purity
HY-P71297 Serpin G1 Protein, Mouse (HEK293, His) P97290 (A20-G504) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12694 SERP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12727 SERPING1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Serping1 NCBI NCBI:710
Rattus norvegicus Serping1 NCBI NCBI:295703