2. Gene
  3. Capn1 - calpain 1 Gene

Capn1 - calpain 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Capa1; Capa-1; mu-calpin

Gene ID: 12333 | Gene type: protein coding

About Capn1

Summary

Enables calcium-dependent cysteine-type endopeptidase activity. Acts upstream of or within mammary gland involution; proteolysis; and receptor catabolic process. Located in cytosol; lysosome; and mitochondrion. Is expressed in molar; oral region epithelium; and skin. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1). [provided by Alliance of Genome Resources, Apr 2022]

Capn1 Products(2)

mRNA Protein Name
NM_001110504.1 NP_001103974.1 calpain-1 catalytic subunit
NM_007600.3 NP_031626.1 calpain-1 catalytic subunit
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium-dependent cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
17529984 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17529984 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within mammary gland involution IMP
IMP: Inferred from mutant phenotype
22555453 MGI
acts upstream of or within proteolysis IMP
IMP: Inferred from mutant phenotype
22555453 MGI
acts upstream of or within receptor catabolic process IDA
IDA: Inferred from direct assay
17529984 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in cytosol IDA
IDA: Inferred from direct assay
22555453 MGI
located in lysosome IDA
IDA: Inferred from direct assay
22555453 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
22555453 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calpain-1 catalytic subunit

CANP 1

calcium-activated neutral proteinase 1

calpain mu-type

calpain-1 large subunit

micromolar-calpain

mu-calpain

muCANP

Recombinant Capn1 Proteins

Cat. No. Product Name Accession Purity
HY-P72114 CAPN1 Protein, Mouse (His) O35350 (M1-A713) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-158022 CTSL/CAPN1-IN-1 Inhibitor / Unkown
HY-161342 CTSL/CAPN1-IN-2 Inhibitor / Unkown
HY-RS01883 CAPN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01895 CAPNS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Capn1 NCBI NCBI:823