WHAMM - WASP homolog associated with actin, golgi membranes and microtubules Gene

Homo sapiens

Also known as WHDC1; WHAMM1

Gene ID: 123720 | Gene type: protein coding

About WHAMM

Cytogenetic location: 15q25.2 Genomic coordinates (GRCh38): 15:82,809,628-82,836,108 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 8.9), spleen (RPKM 2.9) and 24 other tissues.

Summary

This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiates growth of new actin filaments by binding to existing actin filaments. The encoded protein also functions in regulation of transport from the endoplasmic reticulum to the Golgi complex and in maintenance of the Golgi complex near the centrosome. Four pseudogenes of this gene are present on the same arm of chromosome 15 as this gene. [provided by RefSeq, Aug 2013]

WHAMM Products(1)

mRNA	Protein	Name
NM_001080435.3	NP_001073904.1	WASP homolog-associated protein with actin, membranes and microtubules

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Arp2/3 complex binding	IDA IDA: Inferred from direct assay	23087206	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	18614018	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	23087206	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament organization	IDA IDA: Inferred from direct assay	18614018	GOA
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	23087206	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA IDA: Inferred from direct assay	18614018	GOA
involved in focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	23087206	GOA
involved in lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	23087206	GOA
involved in plasma membrane tubulation	IDA IDA: Inferred from direct assay	18614018	GOA
involved in positive regulation of actin nucleation	IDA IDA: Inferred from direct assay	18614018	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	18614018	GOA
located in endoplasmic reticulum-Golgi intermediate compartment membrane	IDA IDA: Inferred from direct assay	18614018	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

WASP homolog-associated protein with actin, membranes and microtubules

WAS protein homolog associated with actin, golgi membranes and microtubules

Related Diseases

Diseases

Alias

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Galloway-Mowat Syndrome

Galloway Mowat Syndrome	Galloway Syndrome
Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type	Microcephaly Nephrosis Syndrome
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Nephrosis Neuronal Dysmigration Syndrome
Microcephaly-Hiatus Hernia-Nephrotic Syndrome	Nephrosis-Neuronal Dysmigration Syndrome

Malignant Otitis Externa

Necrotising Otitis Externa

Pseudomonas Aeruginosa Osteomyelitis Of The Temporal Bone

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15814	WHAMM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WHAMM	VGNC	VGNC:97843
Bos taurus	WHAMM	VGNC	VGNC:53957
Canis familiaris	WHAMM	VGNC	VGNC:53253
Rattus norvegicus	WHAMM	RGD	RGD:1563506
Felis catus	WHAMM	VGNC	VGNC:80783
Mus musculus	WHAMM	MGD	MGI:2142282

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