PLA2G4E - phospholipase A2 group IVE Gene

Homo sapiens

Gene ID: 123745 | Gene type: protein coding

About PLA2G4E

This gene has 9 transcripts (splice variants), 312 orthologues and 5 paralogues. Restricted expression toward skin (RPKM 22.1).

Summary

This gene encodes a member of the cytosolic Phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The Enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The Enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017]

PLA2G4E Products(2)

mRNA	Protein	Name
NM_001206670.1	NP_001193599.1	cytosolic phospholipase A2 epsilon isoform 1
NM_001395548.1	NP_001382477.1	cytosolic phospholipase A2 epsilon isoform 2

PLA2G4E Protein Structure

PLA2_B

0
200
400
600
800
868 a.a.

Protein Preferred Names

Protein Names

cytosolic phospholipase A2 epsilon

cPLA2-epsilon

Related Diseases

Diseases

Alias

Congenital Disorder Of Glycosylation, Type Iic

CDG2C	Congenital Disorder Of Glycosylation Type Iic
Leukocyte Adhesion Deficiency Type Ii	Cdg Iic
Cdgiic	Rambam-Hasharon Syndrome
Leukocyte Adhesion Deficiency, Type Ii	Lad2
Leukocyte Adhesion Deficiency 2	Cdg-Iic
Congenital Disorder Of Glycosylation, Type 2c	Rhs
Cdg Syndrome Type Iic	Lad-Ii
Rambam Hasharon Syndrome	Congenital Disorder Of Glycosylation 2c
Glycosylation, Congenital Disorder Of, Type Iic

Cerebral Creatine Deficiency Syndrome 3

Arginine:Glycine Amidinotransferase Deficiency	Agat Deficiency
Gatm Deficiency	Creatine Deficiency Syndrome Due To Agat Deficiency
L-Arginine:Glycine Amidinotransferase Deficiency	CCDS3
L-Arginine:Glycine Aminidotransferase Deficiency	Deficiency, Cerebral Creatine, Syndrome, Type 3

Ectodermal Dysplasia 9, Hair/Nail Type

ECTD9	Ectodermal Dysplasia 9
Dysplasia, Ectodermal, Type 9, Hair/Nail

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10630	PLA2G4E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PLA2G4E	VGNC	VGNC:44628
Bos taurus	PLA2G4E	VGNC	VGNC:55135
Rattus norvegicus	PLA2G4E	RGD	RGD:1310595
Felis catus	PLA2G4E	VGNC	VGNC:64201
Macaca mulatta	PLA2G4E	VGNC	VGNC:84421
Mus musculus	PLA2G4E	MGD	MGI:1919144

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