LTB4R - leukotriene B4 receptor Gene

Homo sapiens

Also known as BLT1; BLTR; P2Y7; GPR16; LTBR1; P2RY7; CMKRL1; LTB4R1

Gene ID: 1241 | Gene type: protein coding

About LTB4R

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,311,502-24,318,036 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 141 orthologues and 17 paralogues. Biased expression in skin (RPKM 33.9), esophagus (RPKM 9.6) and 10 other tissues.

Summary

Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

LTB4R Products(2)

mRNA	Protein	Name
NM_001143919.3	NP_001137391.1	leukotriene B4 receptor 1
NM_181657.3	NP_858043.1	leukotriene B4 receptor 1

LTB4R Protein Structure

7tm_1

0
100
200
300
352 a.a.

Protein Preferred Names

Protein Names

leukotriene B4 receptor 1

G protein-coupled receptor 16	LTB4-R 1
LTB4-R1	P2Y purinoceptor 7
chemoattractant receptor-like 1	chemokine receptor-like 1
purinergic receptor P2Y, G-protein coupled, 7

Related Diseases

Diseases

Alias

Entropion

Trichomoniasis

Trichomonas Infection	Trichomonas Infections
Disease Due To Trichomonadidae	Infection By Trichomonas
Trichomonadosis	Trichomonas Pruritus
Trichomonosis	Tricomoniasis

Psoriasis 5

PSORS5	Psoriasis Susceptibility 5
Psoriasis 5, Susceptibility To

Persistent Mild Asthma

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Dirofilariasis

Dirofilaria Infectious Disease

Infection By Dirofilaria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07873	LTB4R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07874	Ltb4r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07875	Ltb4r1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07876	LTB4R2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LTB4R	RGD	RGD:620410
Macaca mulatta	LTB4R	VGNC	VGNC:74455
Felis catus	LTB4R	VGNC	VGNC:68102
Mus musculus	LTB4R	MGD	MGI:1309472
Bos taurus	LTB4R	VGNC	VGNC:31069
Canis familiaris	LTB4R	VGNC	VGNC:42855

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