SLC5A10 - solute carrier family 5 member 10 Gene

Homo sapiens

Also known as SGLT5; SGLT-5

Gene ID: 125206 | Gene type: protein coding

About SLC5A10

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,950,676-19,022,565 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 11 paralogues. Biased expression in kidney (RPKM 27.8), skin (RPKM 6.0) and 1 other tissue.

Summary

This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

SLC5A10 Products(5)

mRNA	Protein	Name
NM_001042450.4	NP_001035915.1	sodium/glucose cotransporter 5 isoform 2
NM_001270648.3	NP_001257577.1	sodium/glucose cotransporter 5 isoform 3
NM_001270649.2	NP_001257578.1	sodium/glucose cotransporter 5 isoform 4
NM_001282417.1	NP_001269346.1	sodium/glucose cotransporter 5 isoform 5
NM_152351.6	NP_689564.3	sodium/glucose cotransporter 5 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables fructose:sodium symporter activity	IDA IDA: Inferred from direct assay	22212718	GOA
enables mannose:sodium symporter activity	IDA IDA: Inferred from direct assay	22212718	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC5A10 Protein Structure

SSF

0
100
200
300
400
500
596 a.a.

Protein Preferred Names

Protein Names

sodium/glucose cotransporter 5

Na(+)/glucose cotransporter 5

Related Diseases

Diseases

Alias

Histidinemia

Histidine Ammonia-Lyase Deficiency	Hal Deficiency
Histidase Deficiency	His Deficiency
Histidinuria	Hyperhistidinemia
HISTID	Histidinuria Renal Tubular Defect

Histidine Metabolism Disease

Disturbances Of Histidine Metabolism	Disorder Of Histidine Metabolism
Disturbance Of Histidine Metabolism

Iminoglycinuria

Iminoglycinuria, Digenic

Benign Familial Infantile Epilepsy

Benign Familial Infantile Seizures	Bfie
Benign Familial Infantile Convulsion	Bfic
Bfis	Benign Familial Infantile Convulsions
Familial Benign Neonatal Epilepsy	Watanabe-Vigevano Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13283	SLC5A10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC5A10	VGNC	VGNC:34903
Canis familiaris	SLC5A10	VGNC	VGNC:46443
Rattus norvegicus	SLC5A10	RGD	RGD:1305232
Felis catus	SLC5A10	VGNC	VGNC:65399
Mus musculus	SLC5A10	MGD	MGI:1926089
Macaca mulatta	SLC5A10	VGNC	VGNC:77760

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