Cfh - complement component factor h Gene

Mus musculus

Also known as NOM; Sas1; Mud-1; Sas-1

Gene ID: 12628 | Gene type: protein coding

About Cfh

Summary

Enables complement component C3b binding activity and heparin binding activity. Acts upstream of or within several processes, including animal organ development; complement activation; and vasculature development. Located in several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including adrenal gland; bone; central nervous system; humerus cartilage condensation; and metanephros. Used to study age related macular degeneration 4; atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; and membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to several human genes including CFH (complement Factor H). [provided by Alliance of Genome Resources, Apr 2022]

Cfh Products(1)

mRNA	Protein	Name
NM_009888.3	NP_034018.2	complement factor H precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables complement component C3b binding	IPI IPI: Inferred from physical interaction	16023208	MGI
enables heparin binding	IDA IDA: Inferred from direct assay	16023208	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23487775	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ATP metabolic process	IMP IMP: Inferred from mutant phenotype	26149919	MGI
acts upstream of or within activation of membrane attack complex	IMP IMP: Inferred from mutant phenotype	20813971	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	28057640	MGI
acts upstream of or within bone development	IGI IGI: Inferred from genetic interaction	19828624	MGI
acts upstream of or within cartilage development	IGI IGI: Inferred from genetic interaction	19828624	MGI
acts upstream of or within cellular response to lipopolysaccharide	IGI IGI: Inferred from genetic interaction	19828624	MGI
acts upstream of or within complement activation	IDA IDA: Inferred from direct assay	19411110	MGI
acts upstream of or within complement activation	IGI IGI: Inferred from genetic interaction	20702729	MGI
acts upstream of or within complement activation	IMP IMP: Inferred from mutant phenotype	15574507	MGI
acts upstream of or within complement activation, alternative pathway	IGI IGI: Inferred from genetic interaction	27564415	MGI
acts upstream of or within negative effect complement activation, alternative pathway	IGI IGI: Inferred from genetic interaction	19828624	MGI
acts upstream of or within complement activation, alternative pathway	IMP IMP: Inferred from mutant phenotype	27564415	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	28057640	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	15574507	MGI
acts upstream of or within glomerulus development	IGI IGI: Inferred from genetic interaction	16769899	MGI
acts upstream of or within glomerulus development	IMP IMP: Inferred from mutant phenotype	15574507	MGI
acts upstream of or within immune complex clearance	IGI IGI: Inferred from genetic interaction	20702729	MGI
acts upstream of or within immune response	IMP IMP: Inferred from mutant phenotype	19541934	MGI
acts upstream of or within immunoglobulin mediated immune response	IGI IGI: Inferred from genetic interaction	19828624	MGI
acts upstream of or within inflammatory response	IGI IGI: Inferred from genetic interaction	19828624	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	26149919	MGI
acts upstream of or within inflammatory response to wounding	IGI IGI: Inferred from genetic interaction	21148255	MGI
acts upstream of or within kidney development	IGI IGI: Inferred from genetic interaction	16769899	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	17517971	MGI
acts upstream of or within mitochondrial DNA metabolic process	IMP IMP: Inferred from mutant phenotype	30705315	MGI
acts upstream of or within mitochondrial gene expression	IMP IMP: Inferred from mutant phenotype	26149919	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	30705315	MGI
acts upstream of or within monocyte aggregation	IMP IMP: Inferred from mutant phenotype	28228282	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	29070671	MGI
acts upstream of or within neutrophil homeostasis	IGI IGI: Inferred from genetic interaction	16769899	MGI
acts upstream of or within organ or tissue specific immune response	IGI IGI: Inferred from genetic interaction	20702729	MGI
acts upstream of or within organelle localization	IMP IMP: Inferred from mutant phenotype	17921253	MGI
acts upstream of or within photoreceptor cell differentiation	IMP IMP: Inferred from mutant phenotype	26149919	MGI
acts upstream of or within platelet aggregation	IMP IMP: Inferred from mutant phenotype	28057640	MGI
acts upstream of or within regulation of complement activation	IMP IMP: Inferred from mutant phenotype	18947875	MGI
acts upstream of or within response to cytokine	IDA IDA: Inferred from direct assay	19299737	MGI
acts upstream of or within response to dietary excess	IMP IMP: Inferred from mutant phenotype	25991857	MGI
acts upstream of or within retina development in camera-type eye	IGI IGI: Inferred from genetic interaction	28057640	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	17921253	MGI
acts upstream of or within positive effect retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	30705315	MGI
acts upstream of or within retinal pigment epithelium development	IMP IMP: Inferred from mutant phenotype	23844226	MGI
acts upstream of or within retinal rod cell development	IMP IMP: Inferred from mutant phenotype	17921253	MGI
acts upstream of or within vascular associated smooth muscle cell differentiation	IGI IGI: Inferred from genetic interaction	28057640	MGI
acts upstream of or within vascular associated smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	28057640	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	17517971	MGI
involved in visual perception	IMP IMP: Inferred from mutant phenotype	17921253	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	19299737	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	19299737	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	19411110	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	17028856	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	19299737	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

complement factor H

complement factor H related protein 3A4/5G4

protein beta-1-H

Recombinant Cfh Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7830	Complement factor H/CFH Protein, Mouse (HEK293, His)	E9Q8I0 (S875-V1252)	≥95%
HY-P74232	Complement factor H/CFH Protein, Mouse (HEK293, Fc)	E9Q8I0/NP_034018.2 (S875-V1252)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02561	CFH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cfh	NCBI	NCBI:3075

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