Chil1 - chitinase-like 1 Gene

Mus musculus

Also known as Gp39; Brp39; Chi3l1

Gene ID: 12654 | Gene type: protein coding

About Chil1

Summary

Predicted to enable chitin binding activity. Involved in positive regulation of interleukin-8 production; positive regulation of protein kinase B signaling; and positive regulation of protein phosphorylation. Located in endoplasmic reticulum. Is expressed in alimentary system; limb; and skeleton. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to human CHI3L1 (chitinase 3 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Chil1 Products(2)

mRNA	Protein	Name
NM_001374626.1	NP_001361555.1	chitinase-3-like protein 1 isoform 2 precursor
NM_007695.4	NP_031721.2	chitinase-3-like protein 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23972995	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of NF-kappaB-inducing kinase activity	IDA IDA: Inferred from direct assay	21546314	MGI
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	21546314	MGI
involved in positive regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	21546314	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	21546314	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21546314	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21546314	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

chitinase-3-like protein 1

CGP-39	GP-39
YKL-40	breast regression protein 39
cartilage glycoprotein 39	chitinase 3-like 1

Chil1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Chi3l1	Q61362	Il13ra2	Mus musculus	O88786	Anti Bait CoIP	23972995
Intra	Chi3l1	Q61362	Il13ra2	Mus musculus	O88786	IF	23972995
Intra	Chi3l1	Q61362	Il13ra2	Mus musculus	O88786	Confocal	23972995
Intra	Chi3l1	Q61362	Il13ra2	Mus musculus	O88786	Y2H	23972995

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Chil1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76702	CHI3L1 Protein, Mouse (HEK293, His)	Q61362-2 (Y22-A381)	≥95%

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