Crhr1 - corticotropin releasing hormone receptor 1 Gene

Mus musculus

Also known as Crhr; CRF1R; CRFR1

Gene ID: 12921 | Gene type: protein coding

About Crhr1

Biased expression in cerebellum adult (RPKM 7.7), frontal lobe adult (RPKM 4.7) and 6 other tissues.

Summary

The protein encoded by this gene is a G-protein coupled receptor that binds corticotropin-releasing factor (CRH) and urocortin (UCN) with high affinity. The encoded protein upregulates Adenylate Cyclase activity and intracellular cAMP levels. This protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response, and obesity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Crhr1 Products(3)

mRNA	Protein	Name
NM_007762.5	NP_031788.1	corticotropin-releasing factor receptor 1 isoform 1 precursor
NM_001313929.1	NP_001300858.1	corticotropin-releasing factor receptor 1 isoform 3
NM_001313928.1	NP_001300857.1	corticotropin-releasing factor receptor 1 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables corticotrophin-releasing factor receptor activity	IMP IMP: Inferred from mutant phenotype	9655498	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26352593	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9655498	MGI
involved in adrenal gland development	IMP IMP: Inferred from mutant phenotype	9655498	MGI
acts upstream of or within behavioral response to ethanol	IMP IMP: Inferred from mutant phenotype	11988580	MGI
involved in cellular response to corticotropin-releasing hormone stimulus	IMP IMP: Inferred from mutant phenotype	9655498	MGI
involved in corticotropin secretion	IMP IMP: Inferred from mutant phenotype	9655498	MGI
acts upstream of or within exploration behavior	IMP IMP: Inferred from mutant phenotype	29609111	MGI
involved in fear response	IMP IMP: Inferred from mutant phenotype	9655498	MGI
acts upstream of or within general adaptation syndrome, behavioral process	IMP IMP: Inferred from mutant phenotype	11988580	MGI
involved in regulation of corticosterone secretion	IMP IMP: Inferred from mutant phenotype	9655498	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15183503	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	15183503	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Crhr1 Protein Structure

HormR

7tmB1_CRF-R1

0
100
200
300
415 a.a.

Protein Preferred Names

Protein Names

corticotropin-releasing factor receptor 1

CRF 1 receptor	CRF-R-1
CRF-R1	CRF-R1alpha
CRFR-1	CRH-R-1
CRH-R1

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103377	Antalarmin hydrochloride	Antagonist	99.87%	Unkown
HY-124475	Antalarmin	Antagonist	/	Unkown
HY-12131	DMP 696	Antagonist	99.03%	Unkown
HY-RS03168	CRHR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03169	Crhr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03170	Crhr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crhr1	NCBI	NCBI:1394

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