TAF8 - TATA-box binding protein associated factor 8 Gene

Homo sapiens

Also known as II; TAF; TBN; NEDMLHB; TAFII43; TAFII-43; TAF(II)43

Gene ID: 129685 | Gene type: protein coding

About TAF8

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,050,524-42,087,462 (from NCBI)

This gene has 20 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in thyroid (RPKM 3.7), lymph node (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and Other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

TAF8 Products(3)

mRNA	Protein	Name
NM_001410906.1	NP_001397835.1	transcription initiation factor TFIID subunit 8 isoform 2
NM_001410907.1	NP_001397836.1	transcription initiation factor TFIID subunit 8 isoform 3
NM_138572.3	NP_612639.2	transcription initiation factor TFIID subunit 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15870280	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA-templated transcription open complex formation	IDA IDA: Inferred from direct assay	14580349	GOA
involved in RNA polymerase II preinitiation complex assembly	IPI IPI: Inferred from physical interaction	27007846	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in maintenance of protein location in nucleus	IDA IDA: Inferred from direct assay	15870280	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
acts upstream of or within regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	14580349	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	EXP EXP: Inferred from Experiment	23332750	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15870280	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15870280	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	14580349	GOA
part of transcription factor TFIID complex	IPI IPI: Inferred from physical interaction	23332750	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF8 Protein Structure

Bromo_TP

TAF8_C

0
100
200
310 a.a.

Protein Preferred Names

Protein Names

transcription initiation factor TFIID subunit 8

TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Severe Motor Impairment, Absent Language, Cerebral Hypomyelination, And Brain Atrophy

NEDMLHB

Corpus Callosum, Partial Agenesis Of, X-Linked

X-Linked Complicated Corpus Callosum Dysgenesis	Corpus Callosum, Partial Agenesis Of
Partial Agenesis Of The Corpus Callosum	Partial Agenesis Of Corpus Callosum
Agenesis Of The Corpus Callosum, X-Linked, Partial	ACCPX
Agenesis, Corpus Callosum, Partial

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Ureterolithiasis

Calculus Of Ureter	Ureteric Stone
Ureteral Calculi	Ureteric Calculus
Stone In The Ureter	Ureter Calculi
Ureteral Calculus Or Stone	Ureterolith
Ureterolithiasis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14176	TAF8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TAF8	MGD	MGI:1926879
Macaca mulatta	TAF8	VGNC	VGNC:78146
Bos taurus	TAF8	VGNC	VGNC:35581
Felis catus	TAF8	VGNC	VGNC:102530
Rattus norvegicus	TAF8	RGD	RGD:1308423
Canis familiaris	TAF8	VGNC	VGNC:47089

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