UBR3 - ubiquitin protein ligase E3 component n-recognin 3 Gene

Homo sapiens

Also known as ZNF650

Gene ID: 130507 | Gene type: protein coding

About UBR3

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:169,827,454-170,084,131 (from NCBI)

This gene has 10 transcripts (splice variants), 215 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 13.7), thyroid (RPKM 11.5) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; sensory perception of smell; and suckling behavior. Predicted to act upstream of or within in utero embryonic development and olfactory behavior. Predicted to be integral component of membrane. Predicted to be part of ubiquitin Ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

UBR3 Products(1)

mRNA	Protein	Name
NM_172070.4	NP_742067.3	E3 ubiquitin-protein ligase UBR3

UBR3 Protein Structure

zf-UBR

0
300
600
900
1200
1500
1888 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase UBR3

N-recognin-3

Related Diseases

Diseases

Alias

Johanson-Blizzard Syndrome

JBS	Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness
Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness	Johanson Blizzard Syndrome

Myh-9 Related Disease

Myh9-Related Disease	Myh9-Rd
Myh9-Related Disorder	Myh9-Related Syndrome
Myh9-Related Syndromic Thrombocytopenia	Sebastian Syndrome

Usher Syndrome, Type I

USH1	Usher Syndrome Type 1
Us1	Usher Syndrome, Type 1b
Usher Syndrome Type 1e	Retinitis Pigmentosa And Congenital Deafness
Usher Syndrome, Type Ie	USH1E
Usher Syndrome, Type 1e	Usher Syndrome, Type 1a
Usher Syndrome, Type Ib	Usher Syndrome Type 1b
Usher Syndrome Type Ie	Usher Syndrome Type I
Usher 1	Usher Syndrome, Type 1
Ush1a	Usher Syndrome, Type I, French Variety
Usher Syndrome, Type Ia	Usher Syndrome 1b
USH1B	Usher'S Syndrome Type 1b
Usher Syndrome Type Ib	Ushib

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15388	UBR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBR3	RGD	RGD:1565257
Felis catus	UBR3	VGNC	VGNC:66786
Mus musculus	UBR3	MGD	MGI:1861100
Macaca mulatta	UBR3	VGNC	VGNC:99419
Canis familiaris	UBR3	VGNC	VGNC:53111
Bos taurus	UBR3	VGNC	VGNC:55173

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