2. Gene
  3. KCNH8 - potassium voltage-gated channel subfamily H member 8 Gene

KCNH8 - potassium voltage-gated channel subfamily H member 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ELK; ELK1; elk3; Kv12.1

Gene ID: 131096 | Gene type: protein coding

About KCNH8

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:19,148,510-19,535,642 (from NCBI)

This gene has 3 transcripts (splice variants), 221 orthologues and 17 paralogues. Biased expression in brain (RPKM 4.2), adrenal (RPKM 1.5) and 13 other tissues.

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the Potassium Channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. [provided by RefSeq, Jul 2008]

KCNH8 Products(1)

mRNA Protein Name
NM_144633.3 NP_653234.2 potassium voltage-gated channel subfamily H member 8

KCNH8 Protein Structure

PAS_9

PAS_9: PAS domain (40 - 135)

Ion_trans

Ion_trans: Ion transport protein (261 - 469)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (572 - 656)

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  • 1107 a.a.
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily H member 8

ELK channel 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07131 KCNH8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KCNH8 VGNC VGNC:55057
Macaca mulatta KCNH8 VGNC VGNC:73855
Felis catus KCNH8 VGNC VGNC:63039
Canis familiaris KCNH8 VGNC VGNC:42253
Rattus norvegicus KCNH8 RGD RGD:2549
Mus musculus KCNH8 MGD MGI:2445160